Details of the Target

General Information of Target

Target ID LDTP01347
Target Name Sterol O-acyltransferase 2 (SOAT2)
Gene Name SOAT2
Gene ID 8435
Synonyms
ACACT2; ACAT2; Sterol O-acyltransferase 2; EC 2.3.1.26; Acyl-coenzyme A:cholesterol acyltransferase 2; ACAT-2; Cholesterol acyltransferase 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEPGGARLRLQRTEGLGGERERQPCGDGNTETHRAPDLVQWTRHMEAVKAQLLEQAQGQL
RELLDRAMREAIQSYPSQDKPLPPPPPGSLSRTQEPSLGKQKVFIIRKSLLDELMEVQHF
RTIYHMFIAGLCVFIISTLAIDFIDEGRLLLEFDLLIFSFGQLPLALVTWVPMFLSTLLA
PYQALRLWARGTWTQATGLGCALLAAHAVVLCALPVHVAVEHQLPPASRCVLVFEQVRFL
MKSYSFLREAVPGTLRARRGEGIQAPSFSSYLYFLFCPTLIYRETYPRTPYVRWNYVAKN
FAQALGCVLYACFILGRLCVPVFANMSREPFSTRALVLSILHATLPGIFMLLLIFFAFLH
CWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGARARG
VAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFMMHDQRTGPAWNVLMWTM
LFLGQGIQVSLYCQEWYARRHCPLPQATFWGLVTPRSWSCHT
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Membrane-bound acyltransferase family, Sterol o-acyltransferase subfamily
Subcellular location
Endoplasmic reticulum membrane
Function
Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) and linolenoyl-CoA ((9Z,12Z,15Z)-octadecatrienoyl-CoA) as substrates. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa.; [Isoform 2]: Has lower enzymatic activity compared to isoform 1.; [Isoform 3]: Has lower enzymatic activity compared to isoform 1.
TTD ID
T98315
Uniprot ID
O75908
DrugMap ID
TTAK0IN
Ensemble ID
ENST00000301466.8
HGNC ID
HGNC:11178
ChEMBL ID
CHEMBL4465

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A3KAW SNV: p.G306E .
KMCH1 SNV: p.F313L DBIA    Probe Info 
MOLT4 SNV: p.Q101K; p.D142N .
ONS76 SNV: p.V39L DBIA    Probe Info 
SKMEL24 SNV: p.G28R DBIA    Probe Info 
TKKK SNV: p.H434L DBIA    Probe Info 
TOV21G SNV: p.A227D DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C94(0.90)  LDD3311  [1]
NAIA_5
 Probe Info  		C65(0.00); C360(0.00)  LDD2224  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 22RV1 C94(1.19); C389(1.54)  LDD2243  [1]
 LDCM0023  KB03 22RV1 C94(1.27); C389(2.03)  LDD2660  [1]
 LDCM0024  KB05 G361 C94(0.90)  LDD3311  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264