Details of the Target

General Information of Target

Target ID LDTP01343
Target Name Sulfotransferase 1C4 (SULT1C4)
Gene Name SULT1C4
Gene ID 27233
Synonyms
SULT1C2; Sulfotransferase 1C4; ST1C4; EC 2.8.2.1; Sulfotransferase 1C2; SULT1C#2
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MALHDMEDFTFDGTKRLSVNYVKGILQPTDTCDIWDKIWNFQAKPDDLLISTYPKAGTTW
TQEIVELIQNEGDVEKSKRAPTHQRFPFLEMKIPSLGSGLEQAHAMPSPRILKTHLPFHL
LPPSLLEKNCKIIYVARNPKDNMVSYYHFQRMNKALPAPGTWEEYFETFLAGKVCWGSWH
EHVKGWWEAKDKHRILYLFYEDMKKNPKHEIQKLAEFIGKKLDDKVLDKIVHYTSFDVMK
QNPMANYSSIPAEIMDHSISPFMRKGAVGDWKKHFTVAQNERFDEDYKKKMTDTRLTFHF
QF
Target Bioclass
Enzyme
Family
Sulfotransferase 1 family
Subcellular location
Cytoplasm, cytosol
Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic compounds. Can also sulfonate estrogenic compounds, however, the dietary flavonoids (phytoestrogen) and environmental estrogens, like bisphenol A are better substrates than 17beta-estradiol (E2). Mediates the sulfation of doxorubicin and its analog epirubicin, two antitumor anthracyclines.
Uniprot ID
O75897
Ensemble ID
ENST00000272452.7
HGNC ID
HGNC:11457
ChEMBL ID
CHEMBL1743296

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
8505C SNV: p.R16S .
A101D SNV: p.H299Y .
CAMA1 SNV: p.E127Q .
HEC1 SNV: p.G219V .
JURKAT SNV: p.R194H .
MCC13 SNV: p.M91I .
NCIH358 SNV: p.S98Y .
TYKNU SNV: p.T58K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C32(2.27)  LDD3442  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 HuH-1 C32(1.51)  LDD2374  [1]
 LDCM0023  KB03 HuH-1 C32(1.58)  LDD2791  [1]
 LDCM0024  KB05 SNU-423 C32(2.27)  LDD3442  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840