Details of the Target

General Information of Target

Target ID LDTP01326
Target Name Uroplakin-1b (UPK1B)
Gene Name UPK1B
Gene ID 7348
Synonyms
TSPAN20; Uroplakin-1b; UP1b; Tetraspanin-20; Tspan-20; Uroplakin Ib; UPIb
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAKDNSTVRCFQGLLIFGNVIIGCCGIALTAECIFFVSDQHSLYPLLEATDNDDIYGAAW
IGIFVGICLFCLSVLGIVGIMKSSRKILLAYFILMFIVYAFEVASCITAATQQDFFTPNL
FLKQMLERYQNNSPPNNDDQWKNNGVTKTWDRLMLQDNCCGVNGPSDWQKYTSAFRTENN
DADYPWPRQCCVMNNLKEPLNLEACKLGVPGFYHNQGCYELISGPMNRHAWGVAWFGFAI
LCWTFWVLLGTMFYWSRIEY
Target Bioclass
Transporter and channel
Family
Tetraspanin (TM4SF) family
Subcellular location
Membrane
Function
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions.
Uniprot ID
O75841
Ensemble ID
ENST00000264234.8
HGNC ID
HGNC:12578

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C205(3.71); C218(2.08)  LDD3365  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A-549 C205(2.31)  LDD2260  [1]
 LDCM0023  KB03 ABC-1 C205(16.54)  LDD2679  [1]
 LDCM0024  KB05 OVCAR-3 C205(3.71); C218(2.08)  LDD3365  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840