Details of the Target

General Information of Target

Target ID LDTP01313
Target Name Zinc finger MYND domain-containing protein 10 (ZMYND10)
Gene Name ZMYND10
Gene ID 51364
Synonyms
BLU; Zinc finger MYND domain-containing protein 10; Protein BLu
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGDLELLLPGEAEVLVRGLRSFPLREMGSEGWNQQHENLEKLNMQAILDATVSQGEPIQE
LLVTHGKVPTLVEELIAVEMWKQKVFPVFCRVEDFKPQNTFPIYMVVHHEASIINLLETV
FFHKEVCESAEDTVLDLVDYCHRKLTLLVAQSGCGGPPEGEGSQDSNPMQELQKQAELME
FEIALKALSVLRYITDCVDSLSLSTLSRMLSTHNLPCLLVELLEHSPWSRREGGKLQQFE
GSRWHTVAPSEQQKLSKLDGQVWIALYNLLLSPEAQARYCLTSFAKGRLLKLRAFLTDTL
LDQLPNLAHLQSFLAHLTLTETQPPKKDLVLEQIPEIWERLERENRGKWQAIAKHQLQHV
FSPSEQDLRLQARRWAETYRLDVLEAVAPERPRCAYCSAEASKRCSRCQNEWYCCRECQV
KHWEKHGKTCVLAAQGDRAK
Target Bioclass
Other
Family
ZMYND10 family
Subcellular location
Cytoplasm
Function
Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins.
Uniprot ID
O75800
Ensemble ID
ENST00000231749.8
HGNC ID
HGNC:19412

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
IM95 SNV: p.R17W .
JM1 SNV: p.A399T .
MCC13 SNV: p.E110K .
MOLT4 SNV: p.Q35R; p.W349Ter .
SKNSH SNV: p.S21I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C280(66.12)  LDD0209  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 BRX211 C280(1.66)  LDD2268  [2]
 LDCM0023  KB03 Jurkat C280(66.12)  LDD0209  [1]
 LDCM0024  KB05 ZR-75-1 C280(2.83)  LDD3493  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sorting nexin-11 (SNX11) Sorting nexin family Q9Y5W9
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
TSC22 domain family protein 4 (TSC22D4) TSC-22/Dip/Bun family Q9Y3Q8
T-box transcription factor TBX5 (TBX5) . Q99593
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Eukaryotic translation initiation factor 3 subunit M (EIF3M) EIF-3 subunit M family Q7L2H7
Intraflagellar transport protein 43 homolog (IFT43) IFT43 family Q96FT9
NUT family member 1 (NUTM1) NUT family Q86Y26
Cerebellar degeneration-related antigen 1 (CDR1) . P51861
Splicing regulator RBM11 (RBM11) . P57052
WW domain-binding protein 1 (WBP1) . Q96G27

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840