Details of the Target

General Information of Target

Target ID LDTP01240
Target Name Geminin (GMNN)
Gene Name GMNN
Gene ID 51053
Synonyms
Geminin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNPSMKQKQEEIKENIKNSSVPRRTLKMIQPSASGSLVGRENELSAGLSKRKHRNDHLTS
TTSSPGVIVPESSENKNLGGVTQESFDLMIKENPSSQYWKEVAEKRRKALYEALKENEKL
HKEIEQKDNEIARLKKENKELAEVAEHVQYMAELIERLNGEPLDNFESLDNQEFDSEEET
VEDSLVEDSEIGTCAEGTVSSSTDAKPCI
Target Type
Literature-reported
Target Bioclass
Other
Family
Geminin family
Subcellular location
Cytoplasm
Function
Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle. Inhibits histone acetyltransferase activity of KAT7/HBO1 in a CDT1-dependent manner, inhibiting histone H4 acetylation and DNA replication licensing. Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control.
TTD ID
T57387
Uniprot ID
O75496
DrugMap ID
TT390KA
Ensemble ID
ENST00000230056.8
HGNC ID
HGNC:17493
ChEMBL ID
CHEMBL1293278

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HHS-475
 Probe Info  		Y111(0.96)  LDD0264  [1]
HHS-465
 Probe Info  		Y111(10.00)  LDD2237  [2]
ATP probe
 Probe Info  		N.A.  LDD0199  [3]
m-APA
 Probe Info  		N.A.  LDD2231  [4]
SF
 Probe Info  		N.A.  LDD0028  [5]
AOyne
 Probe Info  		13.50  LDD0443  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0116  HHS-0101 DM93 Y111(0.96)  LDD0264  [1]
 LDCM0117  HHS-0201 DM93 Y111(1.20)  LDD0265  [1]
 LDCM0118  HHS-0301 DM93 Y111(1.40)  LDD0266  [1]
 LDCM0119  HHS-0401 DM93 Y111(1.21)  LDD0267  [1]
 LDCM0120  HHS-0701 DM93 Y111(1.27)  LDD0268  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-C9 (HOXC9) Abd-B homeobox family P31274
Zinc finger protein GLIS2 (GLIS2) GLI C2H2-type zinc-finger protein family Q9BZE0
Zinc finger protein 439 (ZNF439) Krueppel C2H2-type zinc-finger protein family Q8NDP4
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclin-dependent kinase inhibitor 2A (CDKN2A) CDKN2 cyclin-dependent kinase inhibitor family P42771
DNA replication factor Cdt1 (CDT1) Cdt1 family Q9H211
Multicilin (MCIDAS) Geminin family D6RGH6
Coiled-coil domain-containing protein 146 (CCDC146) . Q8IYE0
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
Suppressor APC domain-containing protein 2 (SAPCD2) . Q86UD0

References

1 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
2 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
3 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.