Details of the Target
General Information of Target
| Target ID | LDTP01230 | |||||
|---|---|---|---|---|---|---|
| Target Name | Cytokine receptor-like factor 1 (CRLF1) | |||||
| Gene Name | CRLF1 | |||||
| Gene ID | 9244 | |||||
| Synonyms |
Cytokine receptor-like factor 1; Cytokine-like factor 1; CLF-1; ZcytoR5 |
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| 3D Structure | ||||||
| Sequence |
MPAGRRGPAAQSARRPPPLLPLLLLLCVLGAPRAGSGAHTAVISPQDPTLLIGSSLLATC
SVHGDPPGATAEGLYWTLNGRRLPPELSRVLNASTLALALANLNGSRQRSGDNLVCHARD GSILAGSCLYVGLPPEKPVNISCWSKNMKDLTCRWTPGAHGETFLHTNYSLKYKLRWYGQ DNTCEEYHTVGPHSCHIPKDLALFTPYEIWVEATNRLGSARSDVLTLDILDVVTTDPPPD VHVSRVGGLEDQLSVRWVSPPALKDFLFQAKYQIRYRVEDSVDWKVVDDVSNQTSCRLAG LKPGTVYFVQVRCNPFGIYGSKKAGIWSEWSHPTAASTPRSERPGPGGGACEPRGGEPSS GPVRRELKQFLGWLKKHAYCSNLSFRLYDQWRAWMQKSHKTRNQDEGILPSGRRGTARGP AR |
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| Target Type |
Literature-reported
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| Target Bioclass |
Cytokine and receptor
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| Family |
Type I cytokine receptor family, Type 3 subfamily
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| Subcellular location |
Secreted
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| Function | In complex with CLCF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (Probable). May also play a regulatory role in the immune system. | |||||
| TTD ID | ||||||
| Uniprot ID | ||||||
| DrugMap ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C351(2.70) | LDD3341 | [1] | |
|
IPM Probe Info |
 |
C351(0.00); C116(0.00) | LDD0025 | [2] | |
|
JW-RF-010 Probe Info |
 |
C380(0.00); C313(0.00) | LDD0026 | [2] | |
|
TFBX Probe Info |
 |
C313(0.00); C351(0.00); C380(0.00) | LDD0027 | [2] | |
|
Acrolein Probe Info |
 |
N.A. | LDD0217 | [3] | |
|
Methacrolein Probe Info |
 |
N.A. | LDD0218 | [3] | |
Competitor(s) Related to This Target
The Interaction Atlas With This Target
References