Details of the Target

General Information of Target

Target ID LDTP01188
Target Name Ectonucleoside triphosphate diphosphohydrolase 3 (ENTPD3)
Gene Name ENTPD3
Gene ID 956
Synonyms
CD39L3; Ectonucleoside triphosphate diphosphohydrolase 3; NTPDase 3; EC 3.6.1.5; CD39 antigen-like 3; Ecto-ATP diphosphohydrolase 3; Ecto-ATPDase 3; Ecto-ATPase 3; Ecto-apyrase 3; HB6
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MFTVLTRQPCEQAGLKALYRTPTIIALVVLLVSIVVLVSITVIQIHKQEVLPPGLKYGIV
LDAGSSRTTVYVYQWPAEKENNTGVVSQTFKCSVKGSGISSYGNNPQDVPRAFEECMQKV
KGQVPSHLHGSTPIHLGATAGMRLLRLQNETAANEVLESIQSYFKSQPFDFRGAQIISGQ
EEGVYGWITANYLMGNFLEKNLWHMWVHPHGVETTGALDLGGASTQISFVAGEKMDLNTS
DIMQVSLYGYVYTLYTHSFQCYGRNEAEKKFLAMLLQNSPTKNHLTNPCYPRDYSISFTM
GHVFDSLCTVDQRPESYNPNDVITFEGTGDPSLCKEKVASIFDFKACHDQETCSFDGVYQ
PKIKGPFVAFAGFYYTASALNLSGSFSLDTFNSSTWNFCSQNWSQLPLLLPKFDEVYARS
YCFSANYIYHLFVNGYKFTEETWPQIHFEKEVGNSSIAWSLGYMLSLTNQIPAESPLIRL
PIEPPVFVGTLAFFTAAALLCLAFLAYLCSATRRKRHSEHAFDHAVDSD
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
GDA1/CD39 NTPase family
Subcellular location
Cell membrane
Function Has a threefold preference for the hydrolysis of ATP over ADP.
TTD ID
T63168
Uniprot ID
O75355
DrugMap ID
TT7ES5I
Ensemble ID
ENST00000301825.8
HGNC ID
HGNC:3365
ChEMBL ID
CHEMBL5897

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
8305C SNV: p.R514I .
CAL78 SNV: p.E415K .
IPC298 SNV: p.G327E .
LU65 SNV: p.G384S .
RL SNV: p.K56N .
SW837 SNV: p.E233G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C116(1.99)  LDD3393  [1]
ATP probe
 Probe Info  		N.A.  LDD0035  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 DAN-G C116(1.40)  LDD2313  [1]
 LDCM0023  KB03 DAN-G C116(1.68)  LDD2730  [1]
 LDCM0024  KB05 PaTu 8988t C116(1.99)  LDD3393  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glutathione hydrolase 6 (GGT6) Gamma-glutamyltransferase family Q6P531
Tyrosine-protein phosphatase non-receptor type 5 (PTPN5) Protein-tyrosine phosphatase family P54829
ADP-ribosylation factor-like protein 13B (ARL13B) Arf family Q3SXY8
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
LHFPL tetraspan subfamily member 5 protein (LHFPL5) LHFP family Q8TAF8
Transmembrane protein 106A (TMEM106A) TMEM106 family Q96A25
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) BZIP family Q96BA8
Paired-like homeodomain transcription factor LEUTX (LEUTX) Paired homeobox family A8MZ59
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cell surface A33 antigen (GPA33) . Q99795
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interferon gamma receptor 2 (IFNGR2) Type II cytokine receptor family P38484
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Protein FAM209A (FAM209A) FAM209 family Q5JX71
Nesprin-4 (SYNE4) Nesprin family Q8N205
Fibronectin type III domain-containing protein 9 (FNDC9) . Q8TBE3

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096