Details of the Target
General Information of Target
| Target ID | LDTP01187 | |||||
|---|---|---|---|---|---|---|
| Target Name | Ectonucleoside triphosphate diphosphohydrolase 6 (ENTPD6) | |||||
| Gene Name | ENTPD6 | |||||
| Gene ID | 955 | |||||
| Synonyms |
CD39L2; IL6ST2; Ectonucleoside triphosphate diphosphohydrolase 6; NTPDase 6; EC 3.6.1.6; CD39 antigen-like 2 |
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| 3D Structure | ||||||
| Sequence |
MKKGIRYETSRKTSYIFQQPQHGPWQTRMRKISNHGSLRVAKVAYPLGLCVGVFIYVAYI
KWHRATATQAFFSITRAAPGARWGQQAHSPLGTAADGHEVFYGIMFDAGSTGTRVHVFQF TRPPRETPTLTHETFKALKPGLSAYADDVEKSAQGIRELLDVAKQDIPFDFWKATPLVLK ATAGLRLLPGEKAQKLLQKVKKVFKASPFLVGDDCVSIMNGTDEGVSAWITINFLTGSLK TPGGSSVGMLDLGGGSTQIAFLPRVEGTLQASPPGYLTALRMFNRTYKLYSYSYLGLGLM SARLAILGGVEGQPAKDGKELVSPCLSPSFKGEWEHAEVTYRVSGQKAAASLHELCAARV SEVLQNRVHRTEEVKHVDFYAFSYYYDLAAGVGLIDAEKGGSLVVGDFEIAAKYVCRTLE TQPQSSPFSCMDLTYVSLLLQEFGFPRSKVLKLTRKIDNVETSWALGAIFHYIDSLNRQK SPAS |
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| Target Bioclass |
Enzyme
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| Family |
GDA1/CD39 NTPase family
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| Subcellular location |
Golgi apparatus membrane
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| Function |
Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner. Has a strong preference for nucleoside diphosphates, preferentially hydrolyzes GDP, IDP, and UDP, with slower hydrolysis of CDP, ITP, GTP, CTP, ADP, and UTP and virtually no hydrolysis of ATP. The membrane bound form might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| DU145 | SNV: p.H353Q | . | |||
| IGR1 | SNV: p.P46L | DBIA Probe Info | |||
| Ishikawa (Heraklio) 02 ER | SNV: p.Y414H | . | |||
| JURKAT | SNV: p.G345R | . | |||
| MM1S | SNV: p.A271D | . | |||
| RL | SNV: p.L185V | . | |||
| SNGM | SNV: p.S323G | . | |||
| SUPT1 | SNV: p.R6C; p.L280V | . | |||
| SW1116 | SNV: p.R30T | . | |||
| UMUC3 | SNV: p.K61R | . | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C325(2.63) | LDD3312 | [1] | |
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IA-alkyne Probe Info |
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N.A. | LDD0162 | [2] | |
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AOyne Probe Info |
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11.50 | LDD0443 | [3] | |
Competitor(s) Related to This Target
References