Details of the Target

General Information of Target

Target ID LDTP01128
Target Name Microfibrillar-associated protein 3-like (MFAP3L)
Gene Name MFAP3L
Gene ID 9848
Synonyms
KIAA0626; Microfibrillar-associated protein 3-like; Testis development protein NYD-SP9
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDRLKSHLTVCFLPSVPFLILVSTLATAKSVTNSTLNGTNVVLGSVPVIIARTDHIIVKE
GNSALINCSVYGIPDPQFKWYNSIGKLLKEEEDEKERGGGKWQMHDSGLLNITKVSFSDR
GKYTCVASNIYGTVNNTVTLRVIFTSGDMGVYYMVVCLVAFTIVMVLNITRLCMMSSHLK
KTEKAINEFFRTEGAEKLQKAFEIAKRIPIITSAKTLELAKVTQFKTMEFARYIEELARS
VPLPPLIMNCRTIMEEIMEVVGLEEQGQNFVRHTPEGQEAADRDEVYTIPNSLKRSDSPA
ADSDASSLHEQPQQIAIKVSVHPQSKKEHADDQEGGQFEVKDVEETELSAEHSPETAEPS
TDVTSTELTSEEPTPVEVPDKVLPPAYLEATEPAVTHDKNTCIIYESHV
Target Bioclass
Immunoglobulin
Subcellular location
Cell membrane
Function May participate in the nuclear signaling of EGFR and MAPK1/ERK2. May a have a role in metastasis.
Uniprot ID
O75121
Ensemble ID
ENST00000361618.4
HGNC ID
HGNC:29083

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
EFO27 SNV: p.A305V .
JHH1 SNV: p.R97S .
MEWO SNV: p.P14L .
NCIH716 SNV: p.S298P .
SNU5 SNV: p.S298P .
SW620 SNV: p.A316S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C402(1.19)  LDD3386  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 AU565 C402(1.37); C250(2.21)  LDD2265  [1]
 LDCM0023  KB03 AU565 C402(1.10); C250(8.05)  LDD2682  [1]
 LDCM0024  KB05 OVK-18 C402(1.19)  LDD3386  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840