Details of the Target
General Information of Target
| Target ID | LDTP01120 | |||||
|---|---|---|---|---|---|---|
| Target Name | Slit homolog 1 protein (SLIT1) | |||||
| Gene Name | SLIT1 | |||||
| Gene ID | 6585 | |||||
| Synonyms |
KIAA0813; MEGF4; SLIL1; Slit homolog 1 protein; Slit-1; Multiple epidermal growth factor-like domains protein 4; Multiple EGF-like domains protein 4 |
|||||
| 3D Structure | ||||||
| Sequence |
MALTPGWGSSAGPVRPELWLLLWAAAWRLGASACPALCTCTGTTVDCHGTGLQAIPKNIP
RNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQ LHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRAL RGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFT QCSGPASLRGLNVAEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGL TAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLN SLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSL AKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIETSGARCASPRRLANKRIGQI KSKKFRCSAKEQYFIPGTEDYQLNSECNSDVVCPHKCRCEANVVECSSLKLTKIPERIPQ STAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQ LESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTL QSLSTLNLLANPFNCNCQLAWLGGWLRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFRCE EGQEEGGCLPRPQCPQECACLDTVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVPGQL STFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLH GNDISTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVKTGYKEPGIARCAGPQDME GKLLLTTPAKKFECQGPPTLAVQAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRD CEVSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVC VDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNC SENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGA NCVDQGNRPVCQCLPGFGGPECEKLLSVNFVDRDTYLQFTDLQNWPRANITLQVSTAEDN GILLYNGDNDHIAVELYQGHVRVSYDPGSYPSSAIYSAETINDGQFHTVELVAFDQMVNL SIDGGSPMTMDNFGKHYTLNSEAPLYVGGMPVDVNSAAFRLWQILNGTGFHGCIRNLYIN NELQDFTKTQMKPGVVPGCEPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGP CHGHKCVHGQCVPLDALSYSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGA HCVCDPGFSGELCEQESECRGDPVRDFHQVQRGYAICQTTRPLSWVECRGSCPGQGCCQG LRLKRRKFTFECSDGTSFAEEVEKPTKCGCALCA |
|||||
| Target Bioclass |
Transporter and channel
|
|||||
| Subcellular location |
Secreted
|
|||||
| Function |
Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb.
|
|||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| DU145 | SNV: p.M108T | . | |||
| EFO27 | SNV: p.D658N | . | |||
| ETK1 | SNV: p.Q723H | . | |||
| HEC1 | SNV: p.P1149A | . | |||
| HEC1B | SNV: p.P1149A | . | |||
| HT115 | SNV: p.G1424A | . | |||
| HT1197 | Insertion: p.C940LfsTer7 | . | |||
| IM95 | SNV: p.A1096P | . | |||
| Ishikawa (Heraklio) 02 ER | SNV: p.C517Y | . | |||
| JURKAT | SNV: p.A437T | . | |||
| KELLY | SNV: p.Q146H | . | |||
| KMRC1 | SNV: p.P1333S | . | |||
| MDAMB453 | SNV: p.A827V | . | |||
| MDST8 | Substitution: p.G864I | . | |||
| MFE319 | SNV: p.R637C; p.G1139R | . | |||
| MOLT4 | SNV: p.R476C | IA-alkyne Probe Info | |||
| NCIH1793 | SNV: p.L567Q | . | |||
| NCIH1993 | SNV: p.V14G | . | |||
| ONS76 | SNV: p.R1148K | . | |||
| OVCAR5 | SNV: p.Y1105S | . | |||
| RKO | SNV: p.E536K | . | |||
| SAOS2 | SNV: p.G244V | . | |||
| SBC5 | SNV: p.R374L; p.G1077S | . | |||
| SKHEP1 | SNV: p.S9Y | . | |||
| SNGM | SNV: p.G70C | . | |||
| SW1271 | SNV: p.N215K; p.L831F; p.Q915L | . | |||
| SW1573 | SNV: p.D500G | . | |||
| TCCSUP | SNV: p.G1439R | . | |||
| THP1 | SNV: p.Q266R | . | |||
| WM1552C | SNV: p.D1462Y | . | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C893(2.04); C914(2.38); C242(1.99) | LDD2469 | [1] | |
|
IA-alkyne Probe Info |
 |
C893(0.00); C242(0.00) | LDD0166 | [2] | |
|
VSF Probe Info |
 |
N.A. | LDD0007 | [3] | |
Competitor(s) Related to This Target
The Interaction Atlas With This Target
The Protein(s) Related To This Target
Enzyme
| Protein name | Family | Uniprot ID | |||
|---|---|---|---|---|---|
| Tripartite motif-containing protein 42 (TRIM42) | TRIM/RBCC family | Q8IWZ5 | |||
Transcription factor
| Protein name | Family | Uniprot ID | |||
|---|---|---|---|---|---|
| Homeobox protein Hox-A1 (HOXA1) | Antp homeobox family | P49639 | |||
| Zinc finger protein 620 (ZNF620) | Krueppel C2H2-type zinc-finger protein family | Q6ZNG0 | |||
Other
References