Details of the Target
General Information of Target
| Target ID | LDTP01115 | |||||
|---|---|---|---|---|---|---|
| Target Name | Disintegrin and metalloproteinase domain-containing protein 23 (ADAM23) |
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| Gene Name | ADAM23 | |||||
| Gene ID | 8745 | |||||
| Synonyms |
MDC3; Disintegrin and metalloproteinase domain-containing protein 23; ADAM 23; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3; MDC-3 |
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| 3D Structure | ||||||
| Sequence |
MKPPGSSSRQPPLAGCSLAGASCGPQRGPAGSVPASAPARTPPCRLLLVLLLLPPLAASS
RPRAWGAAAPSAPHWNETAEKNLGVLADEDNTLQQNSSSNISYSNAMQKEITLPSRLIYY INQDSESPYHVLDTKARHQQKHNKAVHLAQASFQIEAFGSKFILDLILNNGLLSSDYVEI HYENGKPQYSKGGEHCYYHGSIRGVKDSKVALSTCNGLHGMFEDDTFVYMIEPLELVHDE KSTGRPHIIQKTLAGQYSKQMKNLTMERGDQWPFLSELQWLKRRKRAVNPSRGIFEEMKY LELMIVNDHKTYKKHRSSHAHTNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQID ITTNPVQMLHEFSKYRQRIKQHADAVHLISRVTFHYKRSSLSYFGGVCSRTRGVGVNEYG LPMAVAQVLSQSLAQNLGIQWEPSSRKPKCDCTESWGGCIMEETGVSHSRKFSKCSILEY RDFLQRGGGACLFNRPTKLFEPTECGNGYVEAGEECDCGFHVECYGLCCKKCSLSNGAHC SDGPCCNNTSCLFQPRGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGYACNQNQGRCY NGECKTRDNQCQYIWGTKAAGSDKFCYEKLNTEGTEKGNCGKDGDRWIQCSKHDVFCGFL LCTNLTRAPRIGQLQGEIIPTSFYHQGRVIDCSGAHVVLDDDTDVGYVEDGTPCGPSMMC LDRKCLQIQALNMSSCPLDSKGKVCSGHGVCSNEATCICDFTWAGTDCSIRDPVRNLHPP KDEGPKGPSATNLIIGSIAGAILVAAIVLGGTGWGFKNVKKRRFDPTQQGPI |
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| Target Bioclass |
Enzyme
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| Subcellular location |
Secreted; Cell membrane
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| Function | May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| A673 | SNV: p.G5C | . | |||
| CAL27 | SNV: p.Q123E | . | |||
| CAOV3 | SNV: p.K356E | . | |||
| CCSW1 | SNV: p.P25S | . | |||
| DAOY | SNV: p.S717Y | . | |||
| DU145 | SNV: p.P422R | . | |||
| HCC15 | SNV: p.E235D | . | |||
| HCT15 | SNV: p.L347P; p.G537W | . | |||
| HEC1 | SNV: p.G621E | . | |||
| HT115 | SNV: p.W441Ter | . | |||
| HT3 | SNV: p.P581S | . | |||
| JEKO1 | SNV: p.A58S | . | |||
| JURKAT | SNV: p.V416M | . | |||
| NCIH82 | Deletion: p.G15LfsTer148 | . | |||
| OVK18 | SNV: p.N639S | . | |||
| PC3 | SNV: p.V306A | . | |||
| SF295 | SNV: p.L552I | . | |||
| SKMEL3 | SNV: p.E454K | DBIA Probe Info | |||
| U937 | SNV: p.L674I | . | |||
| VMRCRCW | SNV: p.E179A | . | |||
| YSCCC | SNV: p.S317C | . | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C475(1.95) | LDD3419 | [1] | |
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IA-alkyne Probe Info |
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C215(1.50) | LDD2214 | [2] | |
Competitor(s) Related to This Target
References