Details of the Target

General Information of Target

Target ID LDTP01112
Target Name Transmembrane and coiled-coil domains protein 2 (TMCC2)
Gene Name TMCC2
Gene ID 9911
Synonyms
KIAA0481; Transmembrane and coiled-coil domains protein 2; Cerebral protein 11
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKRCRSDELQQQQGEEDGAGLEDAASHLPGADLRPGETTGANSAGGPTSDAGAAAAPNPG
PRSKPPDLKKIQQLSEGSMFGHGLKHLFHSRRRSREREHQTSQDSQQHQQQQGMSDHDSP
DEKERSPEMHRVSYAMSLHDLPARPTAFNRVLQQIRSRPSIKRGASLHSSSGGGSSGSSS
RRTKSSSLEPQRGSPHLLRKAPQDSSLAAILHQHQCRPRSSSTTDTALLLADGSNVYLLA
EEAEGIGDKVDKGDLVALSLPAGHGDTDGPISLDVPDGAPDPQRTKAAIDHLHQKILKIT
EQIKIEQEARDDNVAEYLKLANNADKQQVSRIKQVFEKKNQKSAQTIAQLHKKLEHYRRR
LKEIEQNGPSRQPKDVLRDMQQGLKDVGANVRAGISGFGGGVVEGVKGSLSGLSQATHTA
VVSKPREFASLIRNKFGSADNIAHLKDPLEDGPPEEAARALSGSATLVSSPKYGSDDECS
SASASSAGAGSNSGAGPGGALGSPKSNALYGAPGNLDALLEELREIKEGQSHLEDSMEDL
KTQLQRDYTYMTQCLQEERYRYERLEEQLNDLTELHQNEMTNLKQELASMEEKVAYQSYE
RARDIQEAVESCLTRVTKLELQQQQQQVVQLEGVENANARALLGKFINVILALMAVLLVF
VSTIANFITPLMKTRLRITSTTLLVLVLFLLWKHWDSLTYLLEHVLLPS
Target Bioclass
Other
Family
TEX28 family
Subcellular location
Endoplasmic reticulum membrane
Function May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE.
Uniprot ID
O75069
Ensemble ID
ENST00000329800.7
HGNC ID
HGNC:24239

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A431 SNV: p.Q545H .
CAL148 SNV: p.D277N .
COLO320 SNV: p.S475R .
DOTC24510 SNV: p.S438C .
JURKAT SNV: p.V687I .
MEWO SNV: p.H212Q .
MFE319 SNV: p.Q13R; p.N340S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C554(1.85)  LDD3351  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 NCI-H146 C554(1.44)  LDD2510  [1]
 LDCM0023  KB03 NCI-H146 C554(1.54)  LDD2927  [1]
 LDCM0024  KB05 NCI-H196 C554(1.85)  LDD3351  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840