Details of the Target

General Information of Target

Target ID LDTP01066
Target Name Growth arrest-specific protein 7 (GAS7)
Gene Name GAS7
Gene ID 8522
Synonyms
KIAA0394; Growth arrest-specific protein 7; GAS-7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSGARCRTLYPFSGERHGQGLRFAAGELITLLQVPDGGWWEGEKEDGLRGWFPASYVQLL
EKPGMVPPPPGEESQTVILPPGWQSYLSPQGRRYYVNTTTNETTWERPSSSPGIPASPGS
HRSSLPPTVNGYHASGTPAHPPETAHMSVRKSTGDSQNLGSSSPSKKQSKENTITINCVT
FPHPDTMPEQQLLKPTEWSYCDYFWADKKDPQGNGTVAGFELLLQKQLKGKQMQKEMSEF
IRERIKIEEDYAKNLAKLSQNSLASQEEGSLGEAWAQVKKSLADEAEVHLKFSAKLHSEV
EKPLMNFRENFKKDMKKCDHHIADLRKQLASRYASVEKARKALTERQRDLEMKTQQLEIK
LSNKTEEDIKKARRKSTQAGDDLMRCVDLYNQAQSKWFEEMVTTTLELERLEVERVEMIR
QHLCQYTQLRHETDMFNQSTVEPVDQLLRKVDPAKDRELWVREHKTGNIRPVDMEI
Target Bioclass
Other
Subcellular location
Cytoplasm
Function May play a role in promoting maturation and morphological differentiation of cerebellar neurons.
Uniprot ID
O60861
Ensemble ID
ENST00000323816.8
HGNC ID
HGNC:4169

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C318(2.71); C424(1.46)  LDD3331  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		C318(0.00); C424(0.00)  LDD0038  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [2]
Lodoacetamide azide
 Probe Info  		C386(0.00); C318(0.00)  LDD0037  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A101D C318(2.66); C386(2.55); C424(1.58)  LDD2250  [1]
 LDCM0023  KB03 A101D C318(3.01); C386(3.36)  LDD2667  [1]
 LDCM0024  KB05 MKN-1 C318(2.71); C424(1.46)  LDD3331  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hsp90 co-chaperone Cdc37 (CDC37) CDC37 family Q16543
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
U6 snRNA-associated Sm-like protein LSm4 (LSM4) SnRNP Sm proteins family Q9Y4Z0
Protein YIF1A (YIF1A) YIF1 family O95070
Microspherule protein 1 (MCRS1) . Q96EZ8

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853