General Information of Target

Target ID LDTP01058
Target Name P antigen family member 4 (PAGE4)
Gene Name PAGE4
Gene ID 9506
Synonyms
GAGEC1; P antigen family member 4; PAGE-4; G antigen family C member 1; PAGE-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSARVRSRSRGRGDGQEAPDVVAFVAPGESQQEEPPTDNQDIEPGQEREGTPPIEERKVE
GDCQEMDLEKTRSERGDGSDVKEKTPPNPKHAKTKEAGDGQP
Target Bioclass
Other
Family
GAGE family
Subcellular location
Cytoplasm
Function
Intrinsically disordered protein that potentiates the transcriptional activator activity of JUN. Protects cells from stress-induced apoptosis by inhibiting reactive oxygen species (ROS) production and via regulation of the MAPK signaling pathway.
Uniprot ID
O60829
Ensemble ID
ENST00000218068.7
HGNC ID
HGNC:4108

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C63(1.03)  LDD2297  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 CCK-81 C63(1.03)  LDD2297  [1]
 LDCM0023  KB03 COLO-678 C63(0.61)  LDD2721  [1]
 LDCM0024  KB05 CCK-81 C63(1.01)  LDD3131  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840