General Information of Target

Target ID LDTP01022
Target Name Immunoglobulin mu Fc receptor (FCMR)
Gene Name FCMR
Gene ID 9214
Synonyms
FAIM3; TOSO; Immunoglobulin mu Fc receptor; IgM FcR; Fas apoptotic inhibitory molecule 3; FAIM3; Regulator of Fas-induced apoptosis Toso
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDFWLWPLYFLPVSGALRILPEVKVEGELGGSVTIKCPLPEMHVRIYLCREMAGSGTCGT
VVSTTNFIKAEYKGRVTLKQYPRKNLFLVEVTQLTESDSGVYACGAGMNTDRGKTQKVTL
NVHSEYEPSWEEQPMPETPKWFHLPYLFQMPAYASSSKFVTRVTTPAQRGKVPPVHHSSP
TTQITHRPRVSRASSVAGDKPRTFLPSTTASKISALEGLLKPQTPSYNHHTRLHRQRALD
YGSQSGREGQGFHILIPTILGLFLLALLGLVVKRAVERRKALSRRARRLAVRMRALESSQ
RPRGSPRPRSQNNIYSACPRRARGADAAGTGEAPVPGPGAPLPPAPLQVSESPWLHAPSL
KTSCEYVSLYHQPAAMMEDSDSDDYINVPA
Target Bioclass
Immunoglobulin
Subcellular location
Secreted; Membrane
Function
High-affinity Fc receptor for immunoglobulin M (IgM), both secreted and membrane-bound IgM. Primarily regulates IgM transport and homeostasis. Primarily regulates IgM transport and homeostasis. In lymphoid cells, enables exocytosis of membrane-bound IgM on the plasma membrane as well as endocytosis of IgM-antigen complexes toward lysosomes for degradation. In mucosal epithelium, mediates retrotranscytosis of antigen-IgM complexes across mucosal M cells toward antigen-presenting cells in mucosal lymphoid tissues. Triggers costimulatory signaling and mediates most of IgM effector functions involved in B cell development and primary immune response to infection. Likely limits tonic IgM BCR signaling to self-antigens for proper negative selection of autoreactive B cells in the bone marrow and for the maintenance of regulatory B cell pool in peripheral lymphoid organs. Mediates antibody responses to T cell-dependent and T cell-independent antigens and promotes induction of an efficient neutralizing IgG response. Engages in cross-talk with antigen-receptor signaling via the non-canonical NF-kappa-B, MAP kinases and calcium signaling pathways.
Uniprot ID
O60667
Ensemble ID
ENST00000367091.8
HGNC ID
HGNC:14315

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A498 SNV: p.G261C .
COLO678 SNV: p.L220V .
HEC1 SNV: p.A375V .
HEC1B SNV: p.A375V .
Ishikawa (Heraklio) 02 ER SNV: p.C58F .
OVK18 SNV: p.A266E .
PF382 SNV: p.T185A .
SHP77 SNV: p.P82Q .
SNU869 Substitution: p.G107R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info 
C318(7.31)  LDD1704  [1]
DBIA
 Probe Info 
C318(1.41)  LDD2171  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0020  ARS-1620 HCC44 C318(1.41)  LDD2171  [2]
 LDCM0022  KB02 T cell-activated C318(7.31)  LDD1704  [1]
 LDCM0024  KB05 T cell C318(5.19)  LDD1705  [1]
 LDCM0021  THZ1 HCT 116 C318(1.41)  LDD2173  [2]

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.