Details of the Target

General Information of Target

Target ID LDTP01015
Target Name Clathrin coat assembly protein AP180 (SNAP91)
Gene Name SNAP91
Gene ID 9892
Synonyms
KIAA0656; Clathrin coat assembly protein AP180; 91 kDa synaptosomal-associated protein; Clathrin coat-associated protein AP180; Phosphoprotein F1-20
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSGQTLTDRIAAAQYSVTGSAVARAVCKATTHEVMGPKKKHLDYLIQATNETNVNIPQMA
DTLFERATNSSWVVVFKALVTTHHLMVHGNERFIQYLASRNTLFNLSNFLDKSGSHGYDM
STFIRRYSRYLNEKAFSYRQMAFDFARVKKGADGVMRTMAPEKLLKSMPILQGQIDALLE
FDVHPNELTNGVINAAFMLLFKDLIKLFACYNDGVINLLEKFFEMKKGQCKDALEIYKRF
LTRMTRVSEFLKVAEQVGIDKGDIPDLTQAPSSLMETLEQHLNTLEGKKPGNNEGSGAPS
PLSKSSPATTVTSPNSTPAKTIDTSPPVDLFATASAAVPVSTSKPSSDLLDLQPDFSSGG
AAAAAAPAPPPPAGGATAWGDLLGEDSLAALSSVPSEAQISDPFAPEPTPPTTTAEIATA
SASASTTTTVTAVTAEVDLFGDAFAASPGEAPAASEGAAAPATPTPVAAALDACSGNDPF
APSEGSAEAAPELDLFAMKPPETSVPVVTPTASTAPPVPATAPSPAPAVAAAAAATTAAT
AAATTTTTTSAATATTAPPALDIFGDLFESTPEVAAAPKPDAAPSIDLFSTDAFSSPPQG
ASPVPESSLTADLLSVDAFAAPSPATTASPAKVDSSGVIDLFGDAFGSSASEPQPASQAA
SSSSASADLLAGFGGSFMAPSPSPVTPAQNNLLQPNFEAAFGTTPSTSSSSSFDPSVFDG
LGDLLMPTMAPAGQPAPVSMVPPSPAMAASKALGSDLDSSLASLVGNLGISGTTTKKGDL
QWNAGEKKLTGGANWQPKVAPATWSAGVPPSAPLQGAVPPTSSVPPVAGAPSVGQPGAGF
GMPPAGTGMPMMPQQPVMFAQPMMRPPFGAAAVPGTQLSPSPTPASQSPKKPPAKDPLAD
LNIKDFL
Target Bioclass
Other
Family
PICALM/SNAP91 family
Subcellular location
Cell membrane
Function
Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats.
Uniprot ID
O60641
Ensemble ID
ENST00000369694.7
HGNC ID
HGNC:14986

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A375 SNV: p.L103Q .
CCK81 SNV: p.S2L .
COLO792 SNV: p.G846E .
HCT15 SNV: p.G600V .
IGR1 SNV: p.L63F
Substitution: p.S455F		 .
IPC298 SNV: p.G114E .
KP4 SNV: p.A29V .
LN18 SNV: p.P892R .
MCC13 SNV: p.G643R .
MCF7 SNV: p.A366S .
MDAMB468 SNV: p.A334S .
MEWO SNV: p.N108K; p.G295R; p.G637S; p.P745S .
MFE319 SNV: p.A319T; p.S396F; p.P884L .
NALM6 SNV: p.T540P .
NB1 SNV: p.L282I .
NCIH1793 SNV: p.A415S .
NCIH358 SNV: p.T463S .
NCIH446 SNV: p.G722R .
NCIH716 SNV: p.E279Ter; p.Q280K .
P31FUJ SNV: p.K134N .
PF382 SNV: p.T546A .
SW620 SNV: p.V604M .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y96(12.24)  LDD3495  [1]

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.