Details of the Target

General Information of Target

Target ID LDTP00965
Target Name Glutamate receptor ionotropic, NMDA 3B (GRIN3B)
Gene Name GRIN3B
Gene ID 116444
Synonyms
Glutamate receptor ionotropic, NMDA 3B; GluN3B; N-methyl-D-aspartate receptor subtype 3B; NMDAR3B; NR3B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEFVRALWLGLALALGPGSAGGHPQPCGVLARLGGSVRLGALLPRAPLARARARAALARA
ALAPRLPHNLSLELVVAAPPARDPASLTRGLCQALVPPGVAALLAFPEARPELLQLHFLA
AATETPVLSLLRREARAPLGAPNPFHLQLHWASPLETLLDVLVAVLQAHAWEDVGLALCR
TQDPGGLVALWTSRAGRPPQLVLDLSRRDTGDAGLRARLAPMAAPVGGEAPVPAAVLLGC
DIARARRVLEAVPPGPHWLLGTPLPPKALPTAGLPPGLLALGEVARPPLEAAIHDIVQLV
ARALGSAAQVQPKRALLPAPVNCGDLQPAGPESPGRFLARFLANTSFQGRTGPVWVTGSS
QVHMSRHFKVWSLRRDPRGAPAWATVGSWRDGQLDLEPGGASARPPPPQGAQVWPKLRVV
TLLEHPFVFARDPDEDGQCPAGQLCLDPGTNDSATLDALFAALANGSAPRALRKCCYGYC
IDLLERLAEDTPFDFELYLVGDGKYGALRDGRWTGLVGDLLAGRAHMAVTSFSINSARSQ
VVDFTSPFFSTSLGIMVRARDTASPIGAFMWPLHWSTWLGVFAALHLTALFLTVYEWRSP
YGLTPRGRNRSTVFSYSSALNLCYAILFRRTVSSKTPKCPTGRLLMNLWAIFCLLVLSSY
TANLAAVMVGDKTFEELSGIHDPKLHHPAQGFRFGTVWESSAEAYIKKSFPDMHAHMRRH
SAPTTPRGVAMLTSDPPKLNAFIMDKSLLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQN
SPLTSNLSEFISRYKSSGFIDLLHDKWYKMVPCGKRVFAVTETLQMSIYHFAGLFVLLCL
GLGSALLSSLGEHAFFRLALPRIRKGSRLQYWLHTSQKIHRALNTEPPEGSKEETAEAEP
SGPEVEQQQQQQDQPTAPEGWKRARRAVDKERRVRFLLEPAVVVAPEADAEAEAAPREGP
VWLCSYGRPPAARPTGAPQPGELQELERRIEVARERLRQALVRRGQLLAQLGDSARHRPR
RLLQARAAPAEAPPHSGRPGSQE
Target Bioclass
Transporter and channel
Family
Glutamate-gated ion channel (TC 1.A.10.1) family, NR3B/GRIN3B subfamily
Subcellular location
Cell membrane
Function NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine.
Uniprot ID
O60391
Ensemble ID
ENST00000234389.3
HGNC ID
HGNC:16768
ChEMBL ID
CHEMBL2094124

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0222  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [1]
 LDCM0109  NEM HeLa N.A.  LDD0224  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 19 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Acamprosate Small molecular drug DB00659
Aripiprazole Small molecular drug DB01238
Atomoxetine Small molecular drug DB00289
Dextropropoxyphene Small molecular drug DB00647
Donepezil Small molecular drug DB00843
Enflurane Small molecular drug DB00228
Glycine Small molecular drug DB00145
Halothane Small molecular drug DB01159
Memantine Small molecular drug DB01043
Methadone Small molecular drug DB00333
Milnacipran Small molecular drug DB04896
Orphenadrine Small molecular drug DB01173
Pentobarbital Small molecular drug DB00312
Phenobarbital Small molecular drug DB01174
Prasterone Small molecular drug DB01708
Secobarbital Small molecular drug DB00418
Tramadol Small molecular drug DB00193
Esketamine . DB11823
Fluciclovine (18f) . DB13146
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ketobemidone Small molecular drug DB06738
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Tenocyclidine Small molecular drug DB01520

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.