Details of the Target

General Information of Target

Target ID LDTP00954
Target Name Kinesin-like protein KIF1B (KIF1B)
Gene Name KIF1B
Gene ID 23095
Synonyms
KIAA0591; KIAA1448; Kinesin-like protein KIF1B; Klp
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTSIINPKNPKEAPKSFSFDYSYWSHT
SPEDPCFASQNRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEESQAGIIP
QLCEELFEKINDNCNEEMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVED
LSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKHDNETNLSTEK
VSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVDNCTSKSKKKKK
TDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIKCNAVI
NEDPNAKLVRELKEEVTRLKDLLRAQGLGDIIDIDPLIDDYSGSGSKYLKDFQNNKHRYL
LASENQRPGHFSTASMGSLTSSPSSCSLSSQVGLTSVTSIQERIMSTPGGEEAIERLKES
EKIIAELNETWEEKLRKTEAIRMEREALLAEMGVAIREDGGTLGVFSPKKTPHLVNLNED
PLMSECLLYYIKDGITRVGQADAERRQDIVLSGAHIKEEHCIFRSERSNSGEVIVTLEPC
ERSETYVNGKRVSQPVQLRSGNRIIMGKNHVFRFNHPEQARAEREKTPSAETPSEPVDWT
FAQRELLEKQGIDMKQEMEKRLQEMEILYKKEKEEADLLLEQQRLDYESKLQALQKQVET
RSLAAETTEEEEEEEEVPWTQHEFELAQWAFRKWKSHQFTSLRDLLWGNAVYLKEANAIS
VELKKKVQFQFVLLTDTLYSPLPPELLPTEMEKTHEDRPFPRTVVAVEVQDLKNGATHYW
SLEKLKQRLDLMREMYDRAGEMASSAQDESETTVTGSDPFYDRFHWFKLVGSSPIFHGCV
NERLADRTPSPTFSTADSDITELADEQQDEMEDFDDEAFVDDAGSDAGTEEGSDLFSDGH
DPFYDRSPWFILVGRAFVYLSNLLYPVPLIHRVAIVSEKGEVRGFLRVAVQAIAADEEAP
DYGSGIRQSGTAKISFDNEYFNQSDFSSVAMTRSGLSLEELRIVEGQGQSSEVITPPEEI
SRINDLDLKSSTLLDGKMVMEGFSEEIGNHLKLGSAFTFRVTVLQASGILPEYADIFCQF
NFLHRHDEAFSTEPLKNNGRGSPLAFYHVQNIAVEITESFVDYIKTKPIVFEVFGHYQQH
PLHLQGQELNSPPQPCRRFFPPPMPLSKPVPATKLNTMSKTSLGQSMSKYDLLVWFEISE
LEPTGEYIPAVVDHTAGLPCQGTFLLHQGIQRRITVTIIHEKGSELHWKDVRELVVGRIR
NKPEVDEAAVDAILSLNIISAKYLKSSHNSSRTFYRFEAVWDSSLHNSLLLNRVTPYGEK
IYMTLSAYLELDHCIQPAVITKDVCMVFYSRDAKISPPRSLRSLFGSGYSKSPDSNRVTG
IYELSLCKMSDTGSPGMQRRRRKILDTSVAYVRGEENLAGWRPRGDSLILEHQWELEKLE
LLHEVEKTRHFLLLRERLGDSIPKSLSDSLSPSLSSGTLSTSTSISSQISTTTFESAITP
SESSGYDSGDIESLVDREKELATKCLQLLTHTFNREFSQVHGSVSDCKLSDISPIGRDPS
ESSFSSATLTPSSTCPSLVDSRSNSLDQKTPEANSRASSPCPEFEQFQIVPAVETPYLAR
AGKNEFLNLVPDIEEIRPSSVVSKKGYLHFKEPLYSNWAKHFVVVRRPYVFIYNSDKDPV
ERGIINLSTAQVEYSEDQQAMVKTPNTFAVCTKHRGVLLQALNDKDMNDWLYAFNPLLAG
TIRSKLSRRCPSQSKY
Target Bioclass
Enzyme
Family
TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family, Unc-104 subfamily
Subcellular location
Cytoplasm, cytoskeleton
Function
Motor for anterograde transport of mitochondria. Has a microtubule plus end-directed motility. Isoform 2 is required for induction of neuronal apoptosis.; Isoform 1 mediates the transport of synaptic vesicles in neuronal cells.
Uniprot ID
O60333
Ensemble ID
ENST00000263934.10
HGNC ID
HGNC:16636
ChEMBL ID
CHEMBL5889

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2780 SNV: p.E932G DBIA    Probe Info 
CAL51 SNV: p.R316Q DBIA    Probe Info 
CHL1 SNV: p.T795I DBIA    Probe Info 
ETK1 SNV: p.V376E .
FUOV1 SNV: p.M1406I .
HEC1 SNV: p.T1749I DBIA    Probe Info 
HEC1B SNV: p.T1749I .
HT115 SNV: p.K297N; p.S841Y .
JHH7 SNV: p.E564K .
KMCH1 SNV: p.G1303W .
MCC13 Substitution: p.P986L .
MEC1 SNV: p.K1402E DBIA    Probe Info 
MFE319 SNV: p.E481K .
NCIH446 SNV: p.I223V .
OVK18 SNV: p.I354N; p.R427H DBIA    Probe Info 
REH SNV: p.A1014T .
RL952 SNV: p.R633H DBIA    Probe Info 
SSP25 SNV: p.V376E .
U87MG SNV: p.R1027Q DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y1022(9.29)  LDD3495  [1]
DBIA
 Probe Info  		C1771(3.06); C1447(1.51)  LDD3310  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		C1138(0.00); C66(0.00); C1447(0.00)  LDD0038  [3]
IA-alkyne
 Probe Info  		C26(0.00); C1585(0.00); C546(0.00); C356(0.00)  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C356(0.00); C1607(0.00); C66(0.00); C600(0.00)  LDD0037  [3]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [4]
NAIA_4
 Probe Info  		C1635(0.00); C1661(0.00); C1771(0.00)  LDD2226  [5]
NAIA_5
 Probe Info  		N.A.  LDD2224  [5]
TFBX
 Probe Info  		C356(0.00); C1771(0.00)  LDD0027  [4]
WYneN
 Probe Info  		N.A.  LDD0021  [6]
IPM
 Probe Info  		N.A.  LDD0147  [4]
VSF
 Probe Info  		N.A.  LDD0007  [6]
Acrolein
 Probe Info  		C600(0.00); C1607(0.00)  LDD0217  [7]
AOyne
 Probe Info  		11.80  LDD0443  [8]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C284
 Probe Info  		24.93  LDD1954  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [7]
 LDCM0632  CL-Sc Hep-G2 C356(20.00); C1661(3.90); C1771(0.80)  LDD2227  [5]
 LDCM0022  KB02 HEK-293T C546(1.05)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C546(1.03)  LDD1497  [10]
 LDCM0024  KB05 COLO792 C1771(3.06); C1447(1.51)  LDD3310  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 46 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5'-AMP-activated protein kinase subunit beta-2 (PRKAB2) 5'-AMP-activated protein kinase beta subunit family O43741
Cell division cycle protein 23 homolog (CDC23) APC8/CDC23 family Q9UJX2
Ubiquitin-like-conjugating enzyme ATG10 (ATG10) ATG10 family Q9H0Y0
Glutamine--tRNA ligase (QARS1) Class-I aminoacyl-tRNA synthetase family P47897
Cytochrome b5 (CYB5A) Cytochrome b5 family P00167
Eukaryotic translation initiation factor 3 subunit F (EIF3F) EIF-3 subunit F family O00303
DNA-directed RNA polymerase III subunit RPC6 (POLR3F) Eukaryotic RPC34/RPC39 RNA polymerase subunit family Q9H1D9
FAST kinase domain-containing protein 1, mitochondrial (FASTKD1) FAST kinase family Q53R41
Fructose-1,6-bisphosphatase isozyme 2 (FBP2) FBPase class 1 family O00757
Glucose-fructose oxidoreductase domain-containing protein 1 (GFOD1) Gfo/Idh/MocA family Q9NXC2
Polypeptide N-acetylgalactosaminyltransferase 6 (GALNT6) Glycosyltransferase 2 family Q8NCL4
Eyes absent homolog 3 (EYA3) EYA family Q99504
Phosphatidate phosphatase LPIN1 (LPIN1) Lipin family Q14693
Lysyl oxidase homolog 4 (LOXL4) Lysyl oxidase family Q96JB6
Dihydropyrimidinase-related protein 4 (DPYSL4) Hydantoinase/dihydropyrimidinase family O14531
Dihydropyrimidinase-related protein 5 (DPYSL5) Hydantoinase/dihydropyrimidinase family Q9BPU6
Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 (PCMTD2) L-isoaspartyl/D-aspartyl protein methyltransferase family Q9NV79
Peptidoglycan recognition protein 3 (PGLYRP3) N-acetylmuramoyl-L-alanine amidase 2 family Q96LB9
E3 SUMO-protein ligase NSE2 (NSMCE2) NSE2 family Q96MF7
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase (AGA) Ntn-hydrolase family P20933
Phospholipid phosphatase-related protein type 1 (PLPPR1) PA-phosphatase related phosphoesterase family Q8TBJ4
Ubiquitin thioesterase OTUB1 (OTUB1) Peptidase C65 family Q96FW1
MPN domain-containing protein (MPND) Peptidase M67 family Q8N594
E3 SUMO-protein ligase PIAS1 (PIAS1) PIAS family O75925
Calcium/calmodulin-dependent protein kinase type 1G (CAMK1G) CAMK Ser/Thr protein kinase family Q96NX5
Mitogen-activated protein kinase kinase kinase 5 (MAP3K5) STE Ser/Thr protein kinase family Q99683
Ribose-phosphate pyrophosphokinase 1 (PRPS1) Ribose-phosphate pyrophosphokinase family P60891
Ribose-phosphate pyrophosphokinase 2 (PRPS2) Ribose-phosphate pyrophosphokinase family P11908
Ribonuclease H2 subunit C (RNASEH2C) RNase H2 subunit C family Q8TDP1
E3 ubiquitin-protein ligase RNF10 (RNF10) RNF10 family Q8N5U6
3-ketodihydrosphingosine reductase (KDSR) Short-chain dehydrogenases/reductases (SDR) family Q06136
E3 ubiquitin-protein ligase SIAH1 (SIAH1) SINA (Seven in absentia) family Q8IUQ4
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
SPRY domain-containing SOCS box protein 2 (SPSB2) SPSB family Q99619
Inactive C-alpha-formylglycine-generating enzyme 2 (SUMF2) Sulfatase-modifying factor family Q8NBJ7
Terminal nucleotidyltransferase 5B (TENT5B) TENT family Q96A09
Kinesin-like protein KIF1A (KIF1A) Kinesin family Q12756
E3 ubiquitin-protein ligase TRIM9 (TRIM9) TRIM/RBCC family Q9C026
Ubiquitin-conjugating enzyme E2 E3 (UBE2E3) Ubiquitin-conjugating enzyme family Q969T4
Ubiquitin-conjugating enzyme E2 variant 1 (UBE2V1) Ubiquitin-conjugating enzyme family Q13404
G/T mismatch-specific thymine DNA glycosylase (TDG) TDG/mug family Q13569
Bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7 (JMJD7) . P0C870
E3 ubiquitin-protein ligase RNF138 (RNF138) . Q8WVD3
E3 ubiquitin-protein ligase RNF183 (RNF183) . Q96D59
Methyltransferase-like protein 27 (METTL27) . Q8N6F8
RING finger protein 208 (RNF208) . Q9H0X6
Transporter and channel
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
V-type proton ATPase subunit B, kidney isoform (ATP6V1B1) ATPase alpha/beta chains family P15313
Bcl-2 homologous antagonist/killer (BAK1) Bcl-2 family Q16611
Beclin-1 (BECN1) Beclin family Q14457
Clathrin interactor 1 (CLINT1) Epsin family Q14677
Voltage-dependent anion-selective channel protein 2 (VDAC2) Eukaryotic mitochondrial porin family P45880
Disks large homolog 1 (DLG1) MAGUK family Q12959
Disks large homolog 4 (DLG4) MAGUK family P78352
Aquaporin-8 (AQP8) MIP/aquaporin (TC 1.A.8) family O94778
Alpha-crystallin A chain (CRYAA) Small heat shock protein (HSP20) family P02489
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) Tim17/Tim22/Tim23 family O60830
p53 apoptosis effector related to PMP-22 (PERP) TMEM47 family Q96FX8
Membrane protein MLC1 (MLC1) . Q15049
Syntenin-1 (SDCBP) . O00560
Uncharacterized protein CXorf38 (CXorf38) . Q8TB03
Transcription factor
Click To Hide/Show 26 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-C4 (HOXC4) Antp homeobox family P09017
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Basic leucine zipper transcriptional factor ATF-like (BATF) BZIP family Q16520
Fos-related antigen 1 (FOSL1) BZIP family P15407
Doublesex- and mab-3-related transcription factor A1 (DMRTA1) DMRT family Q5VZB9
Krueppel-like factor 3 (KLF3) Krueppel C2H2-type zinc-finger protein family P57682
Myoneurin (MYNN) Krueppel C2H2-type zinc-finger protein family Q9NPC7
Zinc finger and SCAN domain-containing protein 9 (ZSCAN9) Krueppel C2H2-type zinc-finger protein family O15535
Zinc finger protein 436 (ZNF436) Krueppel C2H2-type zinc-finger protein family Q9C0F3
Zinc finger protein 497 (ZNF497) Krueppel C2H2-type zinc-finger protein family Q6ZNH5
Zinc finger protein 524 (ZNF524) Krueppel C2H2-type zinc-finger protein family Q96C55
Zinc finger protein 57 (ZNF57) Krueppel C2H2-type zinc-finger protein family Q68EA5
Zinc finger protein 572 (ZNF572) Krueppel C2H2-type zinc-finger protein family Q7Z3I7
Zinc finger protein 670 (ZNF670) Krueppel C2H2-type zinc-finger protein family Q9BS34
Zinc finger protein GLI4 (GLI4) Krueppel C2H2-type zinc-finger protein family P10075
Zinc finger protein with KRAB and SCAN domains 8 (ZKSCAN8) Krueppel C2H2-type zinc-finger protein family Q15776
Nuclear receptor subfamily 1 group D member 2 (NR1D2) Nuclear hormone receptor family Q14995
Visual system homeobox 2 (VSX2) Paired homeobox family P58304
PHD finger-like domain-containing protein 5A (PHF5A) PHF5 family Q7RTV0
Krueppel-like factor 15 (KLF15) Sp1 C2H2-type zinc-finger protein family Q9UIH9
Ribosome quality control complex subunit TCF25 (TCF25) TCF25 family Q9BQ70
TSC22 domain family protein 4 (TSC22D4) TSC-22/Dip/Bun family Q9Y3Q8
Zinc finger protein ZXDC (ZXDC) ZXD family Q2QGD7
Achaete-scute homolog 4 (ASCL4) . Q6XD76
LIM/homeobox protein Lhx8 (LHX8) . Q68G74
Zinc finger protein 366 (ZNF366) . Q8N895
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable G-protein coupled receptor 141 (GPR141) G-protein coupled receptor 1 family Q7Z602
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Coiled-coil domain-containing protein 141 (CCDC141) . Q6ZP82
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytokine receptor-like factor 3 (CRLF3) Cytokine receptor-like factor 3 family Q8IUI8
Other
Click To Hide/Show 89 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ankyrin repeat and SOCS box protein 9 (ASB9) Ankyrin SOCS box (ASB) family Q96DX5
Annexin A8 (ANXA8) Annexin family P13928
Acidic leucine-rich nuclear phosphoprotein 32 family member B (ANP32B) ANP32 family Q92688
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 (KCTD13) BACURD family Q8WZ19
Bcl-2-like protein 13 (BCL2L13) Bcl-2 family Q9BXK5
Bcl-2-modifying factor (BMF) Bcl-2 family Q96LC9
Protein BRICK1 (BRK1) BRK1 family Q8WUW1
Fatty acid-binding protein, brain (FABP7) Fatty-acid binding protein (FABP) family O15540
CLIP-associating protein 1 (CLASP1) CLASP family Q7Z460
Conserved oligomeric Golgi complex subunit 8 (COG8) COG8 family Q96MW5
Cytoplasmic FMR1-interacting protein 1 (CYFIP1) CYFIP family Q7L576
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997
Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8L2) EPS8 family Q9H6S3
Epithelial splicing regulatory protein 1 (ESRP1) ESRP family Q6NXG1
Protein pelota homolog (PELO) Eukaryotic release factor 1 family Q9BRX2
Protein FAM163A (FAM163A) FAM163 family Q96GL9
Protein FAM9A (FAM9A) FAM9 family Q8IZU1
Protein FAM98C (FAM98C) FAM98 family Q17RN3
Putative golgin subfamily A member 2B (GOLGA2P5) GOLGA2 family Q9HBQ8
Iron-sulfur cluster assembly 2 homolog, mitochondrial (ISCA2) HesB/IscA family Q86U28
Histone H3.3C (H3-5) Histone H3 family Q6NXT2
Keratin, type I cuticular Ha3-II (KRT33B) Intermediate filament family Q14525
Keratin-like protein KRT222 (KRT222) Intermediate filament family Q8N1A0
Syncoilin (SYNC) Intermediate filament family Q9H7C4
Keratin-associated protein 19-7 (KRTAP19-7) KRTAP type 19 family Q3SYF9
Keratin-associated protein 8-1 (KRTAP8-1) KRTAP type 8 family Q8IUC2
Lebercilin-like protein (LCA5L) LCA5 family O95447
Late cornified envelope protein 1B (LCE1B) LCE family Q5T7P3
Cytosolic iron-sulfur assembly component 2B (CIAO2B) MIP18 family Q9Y3D0
Protein Mis18-alpha (MIS18A) Mis18 family Q9NYP9
Protein Mis18-beta (OIP5) Mis18 family O43482
MORF4 family-associated protein 1 (MRFAP1) MORF4 family-associated protein family Q9Y605
MORF4 family-associated protein 1-like 1 (MRFAP1L1) MORF4 family-associated protein family Q96HT8
Perilipin-2 (PLIN2) Perilipin family Q99541
Keratin-associated protein 13-3 (KRTAP13-3) PMG family Q3SY46
Ski-like protein (SKIL) SKI family P12757
snRNA-activating protein complex subunit 3 (SNAPC3) SNAPC3/SRD2 family Q92966
SNW domain-containing protein 1 (SNW1) SNW family Q13573
Protein sprouty homolog 4 (SPRY4) Sprouty family Q9C004
Signal transducing adapter molecule 2 (STAM2) STAM family O75886
Syndecan-2 (SDC2) Syndecan proteoglycan family P34741
Protein TASOR 2 (TASOR2) TASOR family Q5VWN6
CST complex subunit TEN1 (TEN1) TEN1 family Q86WV5
Transcription elongation factor A protein-like 8 (TCEAL8) TFS-II family Q8IYN2
Tubulin beta-6 chain (TUBB6) Tubulin family Q9BUF5
Small ribosomal subunit protein uS2 (RPSA) Universal ribosomal protein uS2 family P08865
Small ribosomal subunit protein uS8 (RPS15A) Universal ribosomal protein uS8 family P62244
UPF0500 protein C1orf216 (C1orf216) UPF0500 family Q8TAB5
Vacuolar protein sorting-associated protein 37A (VPS37A) VPS37 family Q8NEZ2
WD repeat domain-containing protein 83 (WDR83) WD repeat MORG1 family Q9BRX9
Fasciculation and elongation protein zeta-2 (FEZ2) Zygin family Q9UHY8
Break repair meiotic recombinase recruitment factor 1 (BRME1) . Q0VDD7
CAP-Gly domain-containing linker protein 3 (CLIP3) . Q96DZ5
Chromatin complexes subunit BAP18 (BAP18) . Q8IXM2
Coiled-coil domain-containing protein 9 (CCDC9) . Q9Y3X0
Endothelial cell-specific molecule 1 (ESM1) . Q9NQ30
Ephexin-1 (NGEF) . Q8N5V2
Fanconi anemia group G protein (FANCG) . O15287
Fibronectin type 3 and ankyrin repeat domains protein 1 (FANK1) . Q8TC84
FMR1-interacting protein NUFIP2 (NUFIP2) . Q7Z417
G patch domain and ankyrin repeat-containing protein 1 (GPANK1) . O95872
G-protein-signaling modulator 3 (GPSM3) . Q9Y4H4
Insulin-like growth factor-binding protein 4 (IGFBP4) . P22692
IQ domain-containing protein F2 (IQCF2) . Q8IXL9
IQ motif and ubiquitin-like domain-containing protein (IQUB) . Q8NA54
Kelch-like protein 20 (KLHL20) . Q9Y2M5
Leukocyte receptor cluster member 8 (LENG8) . Q96PV6
Ligand of Numb protein X 2 (LNX2) . Q8N448
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (MAGI1) . Q96QZ7
Methylosome protein WDR77 (WDR77) . Q9BQA1
Nebulette (NEBL) . O76041
Period circadian protein homolog 1 (PER1) . O15534
Pleckstrin homology domain-containing family G member 7 (PLEKHG7) . Q6ZR37
Protein FAM117B (FAM117B) . Q6P1L5
Putative uncharacterized protein RUSC1-AS1 (RUSC1-AS1) . Q66K80
Retinoic acid-induced protein 2 (RAI2) . Q9Y5P3
RING1 and YY1-binding protein (RYBP) . Q8N488
RNA-binding protein 14 (RBM14) . Q96PK6
SH3 domain-containing kinase-binding protein 1 (SH3KBP1) . Q96B97
Shieldin complex subunit 1 (SHLD1) . Q8IYI0
Sperm-associated microtubule inner protein 4 (SPMIP4) . Q8N865
Sprouty-related, EVH1 domain-containing protein 2 (SPRED2) . Q7Z698
Sterile alpha motif domain-containing protein 7 (SAMD7) . Q7Z3H4
Testis-expressed protein 19 (TEX19) . Q8NA77
Transmembrane protein 61 (TMEM61) . Q8N0U2
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1 (ZRSR2P1) . Q15695
Ubiquitin-associated domain-containing protein 1 (UBAC1) . Q9BSL1
Uncharacterized protein C8orf48 (C8orf48) . Q96LL4
Uncharacterized protein KIAA0408 (KIAA0408) . Q6ZU52

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402