Details of the Target
General Information of Target
| Target ID | LDTP00924 | |||||
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| Target Name | Heparan-sulfate 6-O-sulfotransferase 1 (HS6ST1) | |||||
| Gene Name | HS6ST1 | |||||
| Gene ID | 9394 | |||||
| Synonyms |
HS6ST; Heparan-sulfate 6-O-sulfotransferase 1; HS6ST-1; EC 2.8.2.- |
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| 3D Structure | ||||||
| Sequence |
MRRRRAGGRTMVERASKFVLVVAGSVCFMLILYQYAGPGLSLGAPGGRAPPDDLDLFPTP
DPHYEKKYYFPVRELERSLRFDMKGDDVIVFLHIQKTGGTTFGRHLVQNVRLEVPCDCRP GQKKCTCYRPNRRETWLFSRFSTGWSCGLHADWTELTNCVPGVLDRRDSAALRTPRKFYY ITLLRDPVSRYLSEWRHVQRGATWKTSLHMCDGRTPTPEELPPCYEGTDWSGCTLQEFMD CPYNLANNRQVRMLADLSLVGCYNLSFIPEGKRAQLLLESAKKNLRGMAFFGLTEFQRKT QYLFERTFNLKFIRPFMQYNSTRAGGVEVDEDTIRRIEELNDLDMQLYDYAKDLFQQRYQ YKRQLERREQRLRSREERLLHRAKEALPREDADEPGRVPTEDYMSHIIEKW |
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| Target Bioclass |
Enzyme
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| Family |
Sulfotransferase 6 family
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| Subcellular location |
Membrane
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| Function |
6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Critical for normal neuronal development where it may play a role in neuron branching. May also play a role in limb development. May prefer iduronic acid.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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SF Probe Info |
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N.A. | LDD0028 | [1] | |
The Interaction Atlas With This Target