Details of the Target

General Information of Target

Target ID LDTP00923
Target Name Adhesion G protein-coupled receptor B3 (ADGRB3)
Gene Name ADGRB3
Gene ID 577
Synonyms
BAI3; KIAA0550; Adhesion G protein-coupled receptor B3; Brain-specific angiogenesis inhibitor 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKAVRNLLIYIFSTYLLVMFGFNAAQDFWCSTLVKGVIYGSYSVSEMFPKNFTNCTWTLE
NPDPTKYSIYLKFSKKDLSCSNFSLLAYQFDHFSHEKIKDLLRKNHSIMQLCNSKNAFVF
LQYDKNFIQIRRVFPTNFPGLQKKGEEDQKSFFEFLVLNKVSPSQFGCHVLCTWLESCLK
SENGRTESCGIMYTKCTCPQHLGEWGIDDQSLILLNNVVLPLNEQTEGCLTQELQTTQVC
NLTREAKRPPKEEFGMMGDHTIKSQRPRSVHEKRVPQEQADAAKFMAQTGESGVEEWSQW
STCSVTCGQGSQVRTRTCVSPYGTHCSGPLRESRVCNNTALCPVHGVWEEWSPWSLCSFT
CGRGQRTRTRSCTPPQYGGRPCEGPETHHKPCNIALCPVDGQWQEWSSWSQCSVTCSNGT
QQRSRQCTAAAHGGSECRGPWAESRECYNPECTANGQWNQWGHWSGCSKSCDGGWERRIR
TCQGAVITGQQCEGTGEEVRRCNEQRCPAPYEICPEDYLMSMVWKRTPAGDLAFNQCPLN
ATGTTSRRCSLSLHGVAFWEQPSFARCISNEYRHLQHSIKEHLAKGQRMLAGDGMSQVTK
TLLDLTQRKNFYAGDLLMSVEILRNVTDTFKRASYIPASDGVQNFFQIVSNLLDEENKEK
WEDAQQIYPGSIELMQVIEDFIHIVGMGMMDFQNSYLMTGNVVASIQKLPAASVLTDINF
PMKGRKGMVDWARNSEDRVVIPKSIFTPVSSKELDESSVFVLGAVLYKNLDLILPTLRNY
TVINSKIIVVTIRPEPKTTDSFLEIELAHLANGTLNPYCVLWDDSKTNESLGTWSTQGCK
TVLTDASHTKCLCDRLSTFAILAQQPREIIMESSGTPSVTLIVGSGLSCLALITLAVVYA
ALWRYIRSERSIILINFCLSIISSNILILVGQTQTHNKSICTTTTAFLHFFFLASFCWVL
TEAWQSYMAVTGKIRTRLIRKRFLCLGWGLPALVVATSVGFTRTKGYGTDHYCWLSLEGG
LLYAFVGPAAAVVLVNMVIGILVFNKLVSRDGILDKKLKHRAGQMSEPHSGLTLKCAKCG
VVSTTALSATTASNAMASLWSSCVVLPLLALTWMSAVLAMTDKRSILFQILFAVFDSLQG
FVIVMVHCILRREVQDAFRCRLRNCQDPINADSSSSFPNGHAQIMTDFEKDVDIACRSVL
HKDIGPCRAATITGTLSRISLNDDEEEKGTNPEGLSYSTLPGNVISKVIIQQPTGLHMPM
SMNELSNPCLKKENSELRRTVYLCTDDNLRGADMDIVHPQERMMESDYIVMPRSSVNNQP
SMKEESKMNIGMETLPHERLLHYKVNPEFNMNPPVMDQFNMNLEQHLAPQEHMQNLPFEP
RTAVKNFMASELDDNAGLSRSETGSTISMSSLERRKSRYSDLDFEKVMHTRKRHMELFQE
LNQKFQTLDRFRDIPNTSSMENPAPNKNPWDTFKNPSEYPHYTTINVLDTEAKDALELRP
AEWEKCLNLPLDVQEGDFQTEV
Target Bioclass
GPCR
Family
G-protein coupled receptor 2 family, Adhesion G-protein coupled receptor (ADGR) subfamily
Subcellular location
Cell membrane
Function Receptor that plays a role in the regulation of synaptogenesis and dendritic spine formation at least partly via interaction with ELMO1 and RAC1 activity. Promotes myoblast fusion through ELMO/DOCK1.
Uniprot ID
O60242
Ensemble ID
ENST00000370598.6
HGNC ID
HGNC:945

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CALU6 SNV: p.D1051Y .
COLO829 SNV: p.D755N .
CORL88 SNV: p.T961S; p.T1280S .
DAOY SNV: p.D1136Y .
HCC15 SNV: p.Ter1523YextTer8 .
HCT15 SNV: p.Y193H; p.N393D .
HEC1 SNV: p.S639F .
HEC1B SNV: p.S639F .
HT SNV: p.N1462T .
HT115 SNV: p.L709F .
IGR1 SNV: p.P62S; p.W300Ter; p.G310E .
IGROV1 SNV: p.S13F .
Ishikawa (Heraklio) 02 ER SNV: p.K585Q .
J82 SNV: p.I108L .
KMCH1 Substitution: p.E1348S .
LN229 SNV: p.L220F .
LS180 SNV: p.A891V .
LS513 SNV: p.D854Y .
MCAS SNV: p.K125R .
MCC13 SNV: p.P1178S .
MDST8 SNV: p.E1305K .
MELHO SNV: p.E1273K .
MELJUSO SNV: p.E1461K .
MEWO SNV: p.R423K .
NCIH1792 SNV: p.E571D .
NCIH1793 SNV: p.V1297I .
P31FUJ SNV: p.R425Q .
REH SNV: p.R982C .
SKMEL30 SNV: p.R1151W .
SKNAS SNV: p.A1095T .
SW1271 SNV: p.S751L; p.P877H; p.V1310L .
SW837 SNV: p.S911Y .
TE1 SNV: p.Q460H .
TE11 SNV: p.Q457H .
TF1 SNV: p.D259Y .
TOV21G SNV: p.Y123H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C80(0.99)  LDD3354  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0625  F8 Ramos 0.17  LDD2187  [3]
 LDCM0572  Fragment10 Ramos 1.34  LDD2189  [3]
 LDCM0573  Fragment11 Ramos 1.51  LDD2190  [3]
 LDCM0574  Fragment12 Ramos 2.15  LDD2191  [3]
 LDCM0575  Fragment13 Ramos 0.28  LDD2192  [3]
 LDCM0576  Fragment14 Ramos 0.20  LDD2193  [3]
 LDCM0579  Fragment20 Ramos 0.48  LDD2194  [3]
 LDCM0580  Fragment21 Ramos 1.75  LDD2195  [3]
 LDCM0582  Fragment23 Ramos 1.94  LDD2196  [3]
 LDCM0586  Fragment28 Ramos 0.95  LDD2198  [3]
 LDCM0588  Fragment30 Ramos 0.46  LDD2199  [3]
 LDCM0468  Fragment33 Ramos 0.92  LDD2202  [3]
 LDCM0566  Fragment4 Ramos 0.41  LDD2184  [3]
 LDCM0614  Fragment56 Ramos 0.45  LDD2205  [3]
 LDCM0569  Fragment7 Ramos 1.42  LDD2186  [3]
 LDCM0571  Fragment9 Ramos 0.59  LDD2188  [3]
 LDCM0022  KB02 Ramos 0.19  LDD2182  [3]
 LDCM0023  KB03 Ramos 0.57  LDD2183  [3]
 LDCM0024  KB05 NCI-H2122 C80(0.99)  LDD3354  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
TLC domain-containing protein 4 (TLCD4) TLCD4 family Q96MV1
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
High affinity cationic amino acid transporter 1 (SLC7A1) Cationic amino acid transporter (CAT) (TC 2.A.3.3) family P30825
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
G-protein coupled receptor 37-like 1 (GPR37L1) G-protein coupled receptor 1 family O60883
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
G patch domain-containing protein 11 (GPATCH11) GPATCH11 family Q8N954

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578