Details of the Target
General Information of Target
| Target ID | LDTP00898 | |||||
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| Target Name | Growth arrest-specific protein 2 (GAS2) |
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| Gene Name | GAS2 | |||||
| Gene ID | 2620 | |||||
| Synonyms |
Growth arrest-specific protein 2; GAS-2 |
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| 3D Structure | ||||||
| Sequence |
MCTALSPKVRSGPGLSDMHQYSQWLASRHEANLLPMKEDLALWLTNLLGKEITAETFMEK
LDNGALLCQLAETMQEKFKESMDANKPTKNLPLKKIPCKTSAPSGSFFARDNTANFLSWC RDLGVDETCLFESEGLVLHKQPREVCLCLLELGRIAARYGVEPPGLIKLEKEIEQEETLS APSPSPSPSSKSSGKKSTGNLLDDAVKRISEDPPCKCPNKFCVERLSQGRYRVGEKILFI RMLHNKHVMVRVGGGWETFAGYLLKHDPCRMLQISRVDGKTSPIQSKSPTLKDMNPDNYL VVSASYKAKKEIK |
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| Target Bioclass |
Other
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| Family |
GAS2 family
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| Subcellular location |
Cytoplasm, cytoskeleton, stress fiber
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| Function |
May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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IA-alkyne Probe Info |
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C68(1.44) | LDD0304 | [1] | |
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DBIA Probe Info |
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C68(1.22) | LDD3372 | [2] | |
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W1 Probe Info |
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N.A. | LDD0236 | [3] | |
Competitor(s) Related to This Target
The Interaction Atlas With This Target
References