Details of the Target

General Information of Target

Target ID LDTP00896
Target Name Tolloid-like protein 1 (TLL1)
Gene Name TLL1
Gene ID 7092
Synonyms
TLL; Tolloid-like protein 1; EC 3.4.24.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGLGTLSPRMLVWLVASGIVFYGELWVCAGLDYDYTFDGNEEDKTETIDYKDPCKAAVFW
GDIALDDEDLNIFQIDRTIDLTQNPFGNLGHTTGGLGDHAMSKKRGALYQLIDRIRRIGF
GLEQNNTVKGKVPLQFSGQNEKNRVPRAATSRTERIWPGGVIPYVIGGNFTGSQRAMFKQ
AMRHWEKHTCVTFIERSDEESYIVFTYRPCGCCSYVGRRGNGPQAISIGKNCDKFGIVVH
ELGHVIGFWHEHTRPDRDNHVTIIRENIQPGQEYNFLKMEPGEVNSLGERYDFDSIMHYA
RNTFSRGMFLDTILPSRDDNGIRPAIGQRTRLSKGDIAQARKLYRCPACGETLQESNGNL
SSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIEVRDGYWRKSPLL
GRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAICGGEIRKNEGQIQSPNYPD
DYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLEVRDGTSENSPLIGRFCGYD
KPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAKPDRGGCEQRCLNTLGSYQCA
CEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKF
EFFELEGNEVCKYDYVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSK
KGFKAHFFSDKDECSKDNGGCQHECVNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHS
PSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFDGETE
KSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATHSTECGGRLKAESKPRDL
YSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAV
GLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYKSIRYPDTTHTKK
Target Bioclass
Enzyme
Subcellular location
Secreted
Function
Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis.
Uniprot ID
O43897
Ensemble ID
ENST00000061240.7
HGNC ID
HGNC:11843
ChEMBL ID
CHEMBL4295664

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
8305C SNV: p.C599S .
A101D SNV: p.S932F .
A172 SNV: p.G566V .
C32 SNV: p.Q135K .
COLO792 SNV: p.P632S .
DU4475 Deletion: p.K994_F996delinsI .
EFO27 SNV: p.R219Ter .
G361 Substitution: p.G220K .
HCC1937 SNV: p.L688V .
HCT15 SNV: p.E606K; p.K642T .
HS936T SNV: p.R444C .
HT115 SNV: p.K234N .
HT29 SNV: p.E470Ter .
IPC298 SNV: p.L314F .
Ishikawa (Heraklio) 02 ER SNV: p.Q472R .
KYSE30 SNV: p.E661Q .
L428 Deletion: p.L814Ter .
MOLT4 SNV: p.R323C .
OVK18 SNV: p.K813Q .
RKO SNV: p.A455V; p.I812M .
SH4 SNV: p.K468I .
SKMEL5 SNV: p.D899N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		N.A.  LDD0165  [1]

References

1 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060