Details of the Target
General Information of Target
| Target ID | LDTP00881 | |||||
|---|---|---|---|---|---|---|
| Target Name | Beta-1,3-galactosyltransferase 2 (B3GALT2) | |||||
| Gene Name | B3GALT2 | |||||
| Gene ID | 8707 | |||||
| Synonyms |
Beta-1,3-galactosyltransferase 2; Beta-1,3-GalTase 2; Beta3Gal-T2; Beta3GalT2; EC 2.4.1.86; UDP-galactose:2-acetamido-2-deoxy-D-glucose 3beta-galactosyltransferase 2 |
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| 3D Structure | ||||||
| Sequence |
MLQWRRRHCCFAKMTWNAKRSLFRTHLIGVLSLVFLFAMFLFFNHHDWLPGRAGFKENPV
TYTFRGFRSTKSETNHSSLRNIWKETVPQTLRPQTATNSNNTDLSPQGVTGLENTLSANG SIYNEKGTGHPNSYHFKYIINEPEKCQEKSPFLILLIAAEPGQIEARRAIRQTWGNESLA PGIQITRIFLLGLSIKLNGYLQRAILEESRQYHDIIQQEYLDTYYNLTIKTLMGMNWVAT YCPHIPYVMKTDSDMFVNTEYLINKLLKPDLPPRHNYFTGYLMRGYAPNRNKDSKWYMPP DLYPSERYPVFCSGTGYVFSGDLAEKIFKVSLGIRRLHLEDVYVGICLAKLRIDPVPPPN EFVFNHWRVSYSSCKYSHLITSHQFQPSELIKYWNHLQQNKHNACANAAKEKAGRYRHRK LH |
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| Target Bioclass |
Enzyme
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| Family |
Glycosyltransferase 31 family
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| Subcellular location |
Golgi apparatus membrane
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| Function |
Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N-acetylglucosamine (beta-GlcNAc) residue. Can also utilize substrates with a terminal galactose residue, albeit with lower efficiency. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Inactive towards substrates with terminal alpha-N-acetylglucosamine (alpha-GlcNAc) or alpha-N-acetylgalactosamine (alpha-GalNAc) residues.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C405(3.30) | LDD3410 | [1] | |
Competitor(s) Related to This Target