Details of the Target

General Information of Target

Target ID LDTP00879
Target Name Cilia- and flagella-associated protein 410 (CFAP410)
Gene Name CFAP410
Gene ID 755
Synonyms
C21orf2; LRRC76; Cilia- and flagella-associated protein 410; C21orf-HUMF09G8.5; Leucine-rich repeat-containing protein 76; YF5/A2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKLTRKMVLTRAKASELHSVRKLNCWGSRLTDISICQEMPSLEVITLSVNSISTLEPVSR
CQRLSELYLRRNRIPSLAELFYLKGLPRLRVLWLAENPCCGTSPHRYRMTVLRTLPRLQK
LDNQAVTEEELSRALSEGEEITAAPEREGTGHGGPKLCCTLSSLSSAAETGRDPLDSEEE
ATSGAQDERGLKPPSRGQFPSLSARDASSSHRGRNVLTAILLLLRELDAEGLEAVQQTVG
SRLQALRGEEVQEHAE
Target Bioclass
Other
Subcellular location
Mitochondrion
Function Plays a role in cilia formation and/or maintenance. Plays a role in the regulation of cell morphology and cytoskeletal organization. Involved in DNA damage repair.
Uniprot ID
O43822
Ensemble ID
ENST00000325223.7
HGNC ID
HGNC:1260

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HUH1 SNV: p.R21L .
NCIH2286 SNV: p.R70L .
RCC10RGB SNV: p.N97K .
TOV21G SNV: p.R5L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		N.A.  LDD0167  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Maspardin (SPG21) AB hydrolase superfamily Q9NZD8
Germ cell-less protein-like 1 (GMCL1) . Q96IK5
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Copper transport protein ATOX1 (ATOX1) ATX1 family O00244

References

1 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060