Details of the Target

General Information of Target

Target ID LDTP00846
Target Name T-cell leukemia homeobox protein 3 (TLX3)
Gene Name TLX3
Gene ID 30012
Synonyms
HOX11L2; T-cell leukemia homeobox protein 3; Homeobox protein Hox-11L2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEAPASAQTPHPHEPISFGIDQILNSPDQDSAPAPRGPDGASYLGGPPGGRPGATYPSLP
ASFAGLGAPFEDAGSYSVNLSLAPAGVIRVPAHRPLPGAVPPPLPSALPAMPSVPTVSSL
GGLNFPWMESSRRFVKDRFTAAAALTPFTVTRRIGHPYQNRTPPKRKKPRTSFSRVQICE
LEKRFHRQKYLASAERAALAKSLKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQASRLM
LQLQHDAFQKSLNDSIQPDPLCLHNSSLFALQNLQPWEEDSSKVPAVTSLV
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Uniprot ID
O43711
Ensemble ID
ENST00000296921.6
HGNC ID
HGNC:13532

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C179(2.20)  LDD3340  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 D283 Med C179(2.95)  LDD2312  [1]
 LDCM0023  KB03 D283 Med C179(4.17)  LDD2729  [1]
 LDCM0024  KB05 NB1 C179(2.20)  LDD3340  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840