Details of the Target

General Information of Target

Target ID LDTP00834
Target Name LIM domain-binding protein 2 (LDB2)
Gene Name LDB2
Gene ID 9079
Synonyms
CLIM1; LIM domain-binding protein 2; LDB-2; Carboxyl-terminal LIM domain-binding protein 1; CLIM-1; LIM domain-binding factor CLIM1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSTPHDPFYSSPFGPFYRRHTPYMVQPEYRIYEMNKRLQSRTEDSDNLWWDAFATEFFE
DDATLTLSFCLEDGPKRYTIGRTLIPRYFSTVFEGGVTDLYYILKHSKESYHNSSITVDC
DQCTMVTQHGKPMFTKVCTEGRLILEFTFDDLMRIKTWHFTIRQYRELVPRSILAMHAQD
PQVLDQLSKNITRMGLTNFTLNYLRLCVILEPMQELMSRHKTYNLSPRDCLKTCLFQKWQ
RMVAPPAEPTRQPTTKRRKRKNSTSSTSNSSAGNNANSTGSKKKTTAANLSLSSQVPDVM
VVGEPTLMGGEFGDEDERLITRLENTQYDAANGMDDEEDFNNSPALGNNSPWNSKPPATQ
ETKSENPPPQASQ
Target Bioclass
Other
Family
LDB family
Subcellular location
Nucleus
Function Transcription cofactor. Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors.
Uniprot ID
O43679
Ensemble ID
ENST00000304523.10
HGNC ID
HGNC:6533

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.Y78C .
MIAPACA2 SNV: p.N36H .
NCIH1048 Deletion: p.K105NfsTer39 .
NCIH661 SNV: p.Y328C .
OCUG1 SNV: p.D47V .
PF382 SNV: p.R42H DBIA    Probe Info 
SNU1 SNV: p.K131R .
SW837 SNV: p.E324K DBIA    Probe Info 
TF1 SNV: p.I173M DBIA    Probe Info 
UACC257 SNV: p.E304Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C246(1.38)  LDD3310  [1]
IPM
 Probe Info  		C234(3.52)  LDD1702  [2]
NAIA_5
 Probe Info  		N.A.  LDD2223  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C234(3.52)  LDD1702  [2]
 LDCM0022  KB02 22RV1 C246(1.55)  LDD2243  [1]
 LDCM0023  KB03 22RV1 C246(2.38)  LDD2660  [1]
 LDCM0024  KB05 COLO792 C246(1.38)  LDD3310  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264