Details of the Target

General Information of Target

Target ID LDTP00800
Target Name Tumor necrosis factor ligand superfamily member 14 (TNFSF14)
Gene Name TNFSF14
Gene ID 8740
Synonyms
HVEML; LIGHT; Tumor necrosis factor ligand superfamily member 14; Herpes virus entry mediator ligand; HVEM-L; Herpesvirus entry mediator ligand; CD antigen CD258) [Cleaved into: Tumor necrosis factor ligand superfamily member 14, membrane form; Tumor necrosis factor ligand superfamily member 14, soluble form]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEESVVRPSVFVVDGQTDIPFTRLGRSHRRQSCSVARVGLGLLLLLMGAGLAVQGWFLLQ
LHWRLGEMVTRLPDGPAGSWEQLIQERRSHEVNPAAHLTGANSSLTGSGGPLLWETQLGL
AFLRGLSYHDGALVVTKAGYYYIYSKVQLGGVGCPLGLASTITHGLYKRTPRYPEELELL
VSQQSPCGRATSSSRVWWDSSFLGGVVHLEAGEKVVVRVLDERLVRLRDGTRSYFGAFMV
Target Type
Clinical trial
Target Bioclass
Cytokine and receptor
Family
Tumor necrosis factor family
Subcellular location
Secreted; Cell membrane; Cytoplasm
Function
Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Acts as a ligand for TNFRSF14/HVEM. Upon binding to TNFRSF14/HVEM, delivers costimulatory signals to T cells, leading to T cell proliferation and IFNG production.
TTD ID
T48881
Uniprot ID
O43557
DrugMap ID
TTKVENM
Ensemble ID
ENST00000245912.7
HGNC ID
HGNC:11930
ChEMBL ID
CHEMBL3712914

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 Deletion: p.N93TfsTer13 .
HEC1 SNV: p.R228C .
HEC1B SNV: p.R228C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C154(9.69)  LDD1704  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 T cell-activated C154(9.69)  LDD1704  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable palmitoyltransferase ZDHHC24 (ZDHHC24) DHHC palmitoyltransferase family Q6UX98
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Myelin and lymphocyte protein (MAL) MAL family P21145
Uroplakin-2 (UPK2) Uroplakin-2 family O00526
Adiponectin (ADIPOQ) . Q15848
Cytokine and receptor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
C-X-C motif chemokine 9 (CXCL9) Intercrine alpha (chemokine CxC) family Q07325
Tumor necrosis factor receptor superfamily member 14 (TNFRSF14) Tumor necrosis factor receptor superfamily Q92956
Tumor necrosis factor receptor superfamily member 3 (LTBR) . P36941
Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B) . O95407
Other
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Claudin-11 (CLDN11) Claudin family O75508
Protein jagunal homolog 1 (JAGN1) Jagunal family Q8N5M9
LHFPL tetraspan subfamily member 3 protein (LHFPL3) LHFP family Q86UP9
Plasmolipin (PLLP) MAL family Q9Y342
Protein transport protein Sec23A (SEC23A) SEC23/SEC24 family Q15436
Vesicle-trafficking protein SEC22a (SEC22A) Synaptobrevin family Q96IW7
Protein SYS1 homolog (SYS1) SYS1 family Q8N2H4
Bone morphogenetic protein 10 (BMP10) TGF-beta family O95393
Transmembrane protein 11, mitochondrial (TMEM11) TMEM11 family P17152
Olfactomedin-4 (OLFM4) . Q6UX06
Pituitary tumor-transforming gene 1 protein-interacting protein (PTTG1IP) . P53801

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.