Details of the Target

General Information of Target

Target ID LDTP00742
Target Name Protein MTSS 1 (MTSS1)
Gene Name MTSS1
Gene ID 9788
Synonyms
KIAA0429; MIM; Protein MTSS 1; Metastasis suppressor YGL-1; Metastasis suppressor protein 1; Missing in metastasis protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEAVIEKECSALGGLFQTIISDMKGSYPVWEDFINKAGKLQSQLRTTVVAAAAFLDAFQK
VADMATNTRGGTREIGSALTRMCMRHRSIEAKLRQFSSALIDCLINPLQEQMEEWKKVAN
QLDKDHAKEYKKARQEIKKKSSDTLKLQKKAKKGRGDIQPQLDSALQDVNDKYLLLEETE
KQAVRKALIEERGRFCTFISMLRPVIEEEISMLGEITHLQTISEDLKSLTMDPHKLPSSS
EQVILDLKGSDYSWSYQTPPSSPSTTMSRKSSVCSSLNSVNSSDSRSSGSHSHSPSSHYR
YRSSNLAQQAPVRLSSVSSHDSGFISQDAFQSKSPSPMPPEAPNQLSNGFSHYSLSSESH
VGPTGAGLFPHCLPASRLLPRVTSVHLPDYAHYYTIGPGMFPSSQIPSWKDWAKPGPYDQ
PLVNTLQRRKEKREPDPNGGGPTTASGPPAAAEEAQRPRSMTVSAATRPGEEMEACEELA
LALSRGLQLDTQRSSRDSLQCSSGYSTQTTTPCCSEDTIPSQVSDYDYFSVSGDQEADQQ
EFDKSSTIPRNSDISQSYRRMFQAKRPASTAGLPTTLGPAMVTPGVATIRRTPSTKPSVR
RGTIGAGPIPIKTPVIPVKTPTVPDLPGVLPAPPDGPEERGEHSPESPSVGEGPQGVTSM
PSSMWSGQASVNPPLPGPKPSIPEEHRQAIPESEAEDQEREPPSATVSPGQIPESDPADL
SPRDTPQGEDMLNAIRRGVKLKKTTTNDRSAPRFS
Target Bioclass
Other
Family
MTSS family
Subcellular location
Cytoplasm, cytoskeleton
Function May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton.
Uniprot ID
O43312
Ensemble ID
ENST00000325064.9
HGNC ID
HGNC:20443

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.R134C .
DU145 Insertion: p.C274WfsTer11 .
HUPT3 SNV: p.C103R .
IGROV1 Deletion: p.G367AfsTer57 .
KMCH1 SNV: p.T46S .
MOLT4 Deletion: p.R155EfsTer34 .
SKMEL30 SNV: p.P520S .
SKOV3 SNV: p.A57T .
TOV21G SNV: p.S223L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C74(3.24)  LDD3334  [1]
IA-alkyne
 Probe Info  		C274(20.00)  LDD1710  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0281  AC21 HEK-293T C9(0.84)  LDD1520  [3]
 LDCM0289  AC29 HEK-293T C9(1.12)  LDD1528  [3]
 LDCM0298  AC37 HEK-293T C9(1.11)  LDD1537  [3]
 LDCM0307  AC45 HEK-293T C9(0.92)  LDD1546  [3]
 LDCM0312  AC5 HEK-293T C9(1.28)  LDD1551  [3]
 LDCM0316  AC53 HEK-293T C9(1.05)  LDD1555  [3]
 LDCM0325  AC61 HEK-293T C9(1.09)  LDD1564  [3]
 LDCM0248  AKOS034007472 HEK-293T C9(1.21)  LDD1511  [3]
 LDCM0409  CL21 HEK-293T C9(0.87)  LDD1613  [3]
 LDCM0422  CL33 HEK-293T C9(0.90)  LDD1626  [3]
 LDCM0435  CL45 HEK-293T C9(1.01)  LDD1639  [3]
 LDCM0448  CL57 HEK-293T C9(0.92)  LDD1651  [3]
 LDCM0461  CL69 HEK-293T C9(0.80)  LDD1664  [3]
 LDCM0475  CL81 HEK-293T C9(0.94)  LDD1678  [3]
 LDCM0484  CL9 HEK-293T C9(0.89)  LDD1687  [3]
 LDCM0488  CL93 HEK-293T C9(1.03)  LDD1691  [3]
 LDCM0022  KB02 CMK C74(2.72)  LDD2302  [1]
 LDCM0023  KB03 CMK C74(2.57)  LDD2719  [1]
 LDCM0024  KB05 MOLM-16 C74(3.24)  LDD3334  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein MTSS 1 (MTSS1) MTSS family O43312

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402