Details of the Target

General Information of Target

Target ID LDTP00715
Target Name Homeobox protein Hox-C11 (HOXC11)
Gene Name HOXC11
Gene ID 3227
Synonyms
HOX3H; Homeobox protein Hox-C11; Homeobox protein Hox-3H
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFNSVNLGNFCSPSRKERGADFGERGSCASNLYLPSCTYYMPEFSTVSSFLPQAPSRQIS
YPYSAQVPPVREVSYGLEPSGKWHHRNSYSSCYAAADELMHRECLPPSTVTEILMKNEGS
YGGHHHPSAPHATPAGFYSSVNKNSVLPQAFDRFFDNAYCGGGDPPAEPPCSGKGEAKGE
PEAPPASGLASRAEAGAEAEAEEENTNPSSSGSAHSVAKEPAKGAAPNAPRTRKKRCPYS
KFQIRELEREFFFNVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKKLSRDRLQYFSG
NPLL
Target Bioclass
Transcription factor
Family
Abd-B homeobox family
Subcellular location
Nucleus
Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to a promoter element of the lactase-phlorizin hydrolase gene.
Uniprot ID
O43248
Ensemble ID
ENST00000546378.1
HGNC ID
HGNC:5123

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C92(1.23)  LDD1571  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0367  CL1 HEK-293T C92(1.23)  LDD1571  [1]
 LDCM0370  CL101 HEK-293T C92(1.14)  LDD1574  [1]
 LDCM0374  CL105 HEK-293T C92(1.03)  LDD1578  [1]
 LDCM0378  CL109 HEK-293T C92(1.04)  LDD1582  [1]
 LDCM0383  CL113 HEK-293T C92(1.06)  LDD1587  [1]
 LDCM0387  CL117 HEK-293T C92(0.89)  LDD1591  [1]
 LDCM0392  CL121 HEK-293T C92(1.21)  LDD1596  [1]
 LDCM0396  CL125 HEK-293T C92(1.01)  LDD1600  [1]
 LDCM0400  CL13 HEK-293T C92(1.16)  LDD1604  [1]
 LDCM0413  CL25 HEK-293T C92(1.06)  LDD1617  [1]
 LDCM0426  CL37 HEK-293T C92(1.05)  LDD1630  [1]
 LDCM0439  CL49 HEK-293T C92(1.15)  LDD1643  [1]
 LDCM0453  CL61 HEK-293T C92(0.98)  LDD1656  [1]
 LDCM0466  CL73 HEK-293T C92(1.12)  LDD1669  [1]
 LDCM0479  CL85 HEK-293T C92(1.06)  LDD1682  [1]
 LDCM0492  CL97 HEK-293T C92(1.18)  LDD1695  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402