Details of the Target

General Information of Target

Target ID LDTP00683
Target Name Endogenous retrovirus group K member 18 Env polyprotein (ERVK-18)
Gene Name ERVK-18
Synonyms
Endogenous retrovirus group K member 18 Env polyprotein; Envelope polyprotein; HERV-K(C1a) envelope protein; HERV-K110 envelope protein; HERV-K18 envelope protein; HERV-K18 superantigen; HERV-K_1q23.3 provirus ancestral Env polyprotein; IDDMK1,2 22 envelope protein; IDDMK1,2 22 superantigen) [Cleaved into: Surface protein; SU; Transmembrane protein; TM)]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVTPVTWMDNPIEVYVNDSVWVPGPTDDRCPAKPEEEGMMINISIGYHYPPICLGRAPGC
LMPAVQNWLVEVPTVSPNSRFTYHMVSGMSLRPRVNCLQDFSYQRSLKFRPKGKTCPKEI
PKGSKNTEVLVWEECVANSVVILQNNEFGTIIDWAPRGQFYHNCSGQTQSCPSAQVSPAV
DSDLTESLDKHKHKKLQSFYLWEWEEKGISTPRPKIISPVSGPEHPELWRLTVASHHIRI
WSGNQTLETRYRKPFYTIDLNSILTVPLQSCVKPPYMLVVGNIVIKPASQTITCENCRLF
TCIDSTFNWQHRILLVRAREGMWIPVSTDRPWEASPSIHILTEILKGVLNRSKRFIFTLI
AVIMGLIAVTATAAVAGVALHSSVQSVNFVNYWQKNSTRLWNSQSSIDQKLASQINDLRQ
TVIWMGDRLMTLEHHFQLQCDWNTSDFCITPQIYNESEHHWDMVRRHLQGREDNLTLDIS
KLKEQIFEASKAHLNLVPGTEAIAGVADGLANLNPVTWIKTIRSTMIINLILIVVCLFCL
LLVCRCTQQLRRDSDIENGP
Target Bioclass
Other
Family
Beta type-B retroviral envelope protein family, HERV class-II K(HML-2) env subfamily
Subcellular location
Virion; Cell membrane
Function
Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This envelope protein has superantigenic properties.; SU mediates receptor recognition.; TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane.
Uniprot ID
O42043
HGNC ID
HGNC:39025

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CY-1
 Probe Info  		N.A.  LDD0246  [1]

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.