Details of the Target

General Information of Target

Target ID LDTP00677
Target Name P2X purinoceptor 6 (P2RX6)
Gene Name P2RX6
Gene ID 9127
Synonyms
P2RXL1; P2X6; P2X purinoceptor 6; P2X6; ATP receptor; P2XM; Purinergic receptor; Purinergic receptor P2X-like 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MCPQLAGAGSMGSPGATTGWGLLDYKTEKYVMTRNWRVGALQRLLQFGIVVYVVGWALLA
KKGYQERDLEPQFSIITKLKGVSVTQIKELGNRLWDVADFVKPPQGENVFFLVTNFLVTP
AQVQGRCPEHPSVPLANCWVDEDCPEGEGGTHSHGVKTGQCVVFNGTHRTCEIWSWCPVE
SGVVPSRPLLAQAQNFTLFIKNTVTFSKFNFSKSNALETWDPTYFKHCRYEPQFSPYCPV
FRIGDLVAKAGGTFEDLALLGGSVGIRVHWDCDLDTGDSGCWPHYSFQLQEKSYNFRTAT
HWWEQPGVEARTLLKLYGIRFDILVTGQAGKFGLIPTAVTLGTGAAWLGVVTFFCDLLLL
YVDREAHFYWRTKYEEAKAPKATANSVWRELALASQARLAECLRRSSAPAPTATAAGSQT
QTPGWPCPSSDTHLPTHSGSL
Target Bioclass
Transporter and channel
Family
P2X receptor family
Subcellular location
Membrane
Function Receptor for ATP that acts as a ligand-gated ion channel.
Uniprot ID
O15547
Ensemble ID
ENST00000401443.5
HGNC ID
HGNC:8538
ChEMBL ID
CHEMBL2670

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AU565 Deletion: p.K208_F209del .
COLO679 SNV: p.G252E .
DOTC24510 SNV: p.R242G .
DU145 SNV: p.C138Y .
HCT116 SNV: p.Y237Ter .
HCT15 SNV: p.A384T .
NCIH446 SNV: p.W20L .
NCIH716 Substitution: p.T17N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C402(1.17)  LDD1700  [1]
Acrolein
 Probe Info  		N.A.  LDD0217  [2]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [2]
Methacrolein
 Probe Info  		N.A.  LDD0218  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [2]
 LDCM0107  IAA HeLa N.A.  LDD0221  [2]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C402(1.01)  LDD2111  [1]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C402(1.17)  LDD1700  [1]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C402(0.69)  LDD2146  [1]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C402(0.50)  LDD2148  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Promethazine Small molecular drug DB01069

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.