Details of the Target

General Information of Target

Target ID LDTP00673
Target Name Zinc finger and SCAN domain-containing protein 9 (ZSCAN9)
Gene Name ZSCAN9
Gene ID 7746
Synonyms
ZNF193; Zinc finger and SCAN domain-containing protein 9; Cell proliferation-inducing gene 12 protein; PRD51; Zinc finger protein 193
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MNTNSKEVLSLGVQVPEAWEELLTMKVEAKSHLQWQESRLKRSNPLAREIFRRHFRQLCY
QETPGPREALTRLQELCYQWLRPHVSTKEQILDLLVLEQFLSILPKELQGWVREHCPESG
EEAVILLEDLERELDEPQHEMVAHRHRQEVLCKEMVPLAEQTPLTLQSQPKEPQLTCDSA
QKCHSIGETDEVTKTEDRELVLRKDCPKIVEPHGKMFNEQTWEVSQQDPSHGEVGEHKDR
IERQWGNLLGEGQHKCDECGKSFTQSSGLIRHQRIHTGERPYECNECGKAFSRSSGLFNH
RGIHNIQKRYHCKECGKVFSQSAGLIQHQRIHKGEKPYQCSQCSKSYSRRSFLIEHQRSH
TGERPHQCIECGKSFNRHCNLIRHQKIHTVAELV
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
O15535
Ensemble ID
ENST00000252207.10
HGNC ID
HGNC:12984

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.F291L .
G361 SNV: p.Q181Ter .
HCT15 SNV: p.E118Ter .
HDMYZ SNV: p.N218Y .
IGR1 SNV: p.E68Ter .
NCIH1666 SNV: p.C284Y .
TF1 SNV: p.P45A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
N1
 Probe Info  		N.A.  LDD0245  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Serine protease HTRA2, mitochondrial (HTRA2) Peptidase S1C family O43464
Protein kinase C alpha type (PRKCA) AGC Ser/Thr protein kinase family P17252
SRSF protein kinase 2 (SRPK2) CMGC Ser/Thr protein kinase family P78362
Ribose-phosphate pyrophosphokinase 1 (PRPS1) Ribose-phosphate pyrophosphokinase family P60891
GTP-binding protein GEM (GEM) RGK family P55040
F-box only protein 17 (FBXO17) . Q96EF6
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein gamma (YWHAG) 14-3-3 family P61981
Huntingtin (HTT) Huntingtin family P42858
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and SCAN domain-containing protein 22 (ZSCAN22) Krueppel C2H2-type zinc-finger protein family P10073
Zinc finger and SCAN domain-containing protein 23 (ZSCAN23) Krueppel C2H2-type zinc-finger protein family Q3MJ62
Zinc finger protein 446 (ZNF446) Krueppel C2H2-type zinc-finger protein family Q9NWS9
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Progranulin (GRN) Granulin family P28799
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Neurofilament light polypeptide (NEFL) Intermediate filament family P07196
AFG2-interacting ribosome maturation factor (AIRIM) . Q9NX04
Four and a half LIM domains protein 2 (FHL2) . Q14192
Melanoma-associated antigen H1 (MAGEH1) . Q9H213
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.