Details of the Target

General Information of Target

Target ID LDTP00634
Target Name Forkhead box protein P2 (FOXP2)
Gene Name FOXP2
Gene ID 93986
Synonyms
CAGH44; TNRC10; Forkhead box protein P2; CAG repeat protein 44; Trinucleotide repeat-containing gene 10 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMQESATETISNSSMNQNGMSTLSSQLDAGSRDGRSSGDTSSEVSTVELLHLQQQQALQA
ARQLLLQQQTSGLKSPKSSDKQRPLQVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQA
LLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ
QQQQQQQQQQQHPGKQAKEQQQQQQQQQQLAAQQLVFQQQLLQMQQLQQQQHLLSLQRQG
LISIPPGQAALPVQSLPQAGLSPAEIQQLWKEVTGVHSMEDNGIKHGGLDLTTNNSSSTT
SSNTSKASPPITHHSIVNGQSSVLSARRDSSSHEETGASHTLYGHGVCKWPGCESICEDF
GQFLKHLNNEHALDDRSTAQCRVQMQVVQQLEIQLSKERERLQAMMTHLHMRPSEPKPSP
KPLNLVSSVTMSKNMLETSPQSLPQTPTTPTAPVTPITQGPSVITPASVPNVGAIRRRHS
DKYNIPMSSEIAPNYEFYKNADVRPPFTYATLIRQAIMESSDRQLTLNEIYSWFTRTFAY
FRRNAATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEVEYQKRRSQKITGSPTLVKNIPT
SLGYGAALNASLQAALAESSLPLLSNPGLINNASSGLLQAVHEDLNGSLDHIDSNGNSSP
GCSPQPHIHSIHVKEEPVIAEDEDCPMSLVTTANHSPELEDDREIEEEPLSEDLE
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function
Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language.
Uniprot ID
O15409
Ensemble ID
ENST00000350908.9
HGNC ID
HGNC:13875

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
IGROV1 SNV: p.K306R DBIA    Probe Info 
IM95 SNV: p.G283D DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.Q182K DBIA    Probe Info 
KASUMI2 SNV: p.R543H DBIA    Probe Info 
LNCaP clone FGC SNV: p.T593A DBIA    Probe Info 
LS513 SNV: p.S442R .
MEWO SNV: p.E675K DBIA    Probe Info 
NCIH23 SNV: p.L150I DBIA    Probe Info 
P31FUJ SNV: p.T537A DBIA    Probe Info 
RKO SNV: p.R399C DBIA    Probe Info 
SKMEL2 SNV: p.Q176E .
WM2664 SNV: p.K74N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C406(3.35)  LDD3310  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 22RV1 C406(3.16)  LDD2243  [1]
 LDCM0023  KB03 22RV1 C406(3.52)  LDD2660  [1]
 LDCM0024  KB05 COLO792 C406(3.35)  LDD3310  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
C-terminal-binding protein 2 (CTBP2) D-isomer specific 2-hydroxyacid dehydrogenase family P56545
Cyclin-dependent kinase 3 (CDK3) CMGC Ser/Thr protein kinase family Q00526
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) . Q13526
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Syntenin-1 (SDCBP) . O00560
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Forkhead box protein P1 (FOXP1) . Q9H334
Forkhead box protein P2 (FOXP2) . O15409
Forkhead box protein P4 (FOXP4) . Q8IVH2
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclin-C (CCNC) Cyclin family P24863
Protein FAM124A (FAM124A) FAM124 family Q86V42
TSSK6-activating co-chaperone protein (TSACC) TSACC family Q96A04
TLE family member 5 (TLE5) WD repeat Groucho/TLE family Q08117

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840