Details of the Target

General Information of Target

Target ID LDTP00629
Target Name Neural cell adhesion molecule 2 (NCAM2)
Gene Name NCAM2
Gene ID 4685
Synonyms
NCAM21; Neural cell adhesion molecule 2; N-CAM-2; NCAM-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSLLLSFYLLGLLVSSGQALLQVTISLSKVELSVGESKFFTCTAIGEPESIDWYNPQGEK
IISTQRVVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREV
VSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSD
EGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEP
AISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFV
QPHIIQLKNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQH
GSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINI
SCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNH
IGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASE
IWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREPSPPSIH
GQPSSGKSFKLSITKQDDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKDHIILEHLQWTM
GYEVQITAANRLGYSEPTVYEFSMPPKPNIIKDTLFNGLGLGAVIGLGVAALLLILVVTD
VSCFFIRQCGLLMCITRRMCGKKSGSSGKSKELEEGKAAYLKDGSKEPIVEMRTEDERVT
NHEDGSPVNEPNETTPLTEPEKLPLKEEDGKEALNPETIEIKVSNDIIQSKEDDSKA
Target Bioclass
Immunoglobulin
Subcellular location
Cell membrane
Function May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons.
Uniprot ID
O15394
Ensemble ID
ENST00000400546.6
HGNC ID
HGNC:7657

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AU565 SNV: p.E252K .
CAL148 SNV: p.E153K .
FUOV1 SNV: p.M228L .
HCT15 SNV: p.P214H .
IPC298 SNV: p.S426L .
KYSE410 SNV: p.C136S .
LNCaP clone FGC SNV: p.V280F DBIA    Probe Info 
LS123 SNV: p.A283G .
MCC13 SNV: p.S515F; p.G574R .
MDAMB453 SNV: p.R353C DBIA    Probe Info 
MEWO SNV: p.G129R .
NCIH1048 SNV: p.L395I .
NCIH1299 SNV: p.V495L .
REC1 SNV: p.I489T .
RPMI8226 SNV: p.S521F .
SKMEL28 SNV: p.G415E .
SW1271 SNV: p.S835C .
WM2664 SNV: p.E820Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K575(9.09)  LDD0277  [1]
DBIA
 Probe Info  		C405(2.65)  LDD3345  [2]
Acrolein
 Probe Info  		N.A.  LDD0217  [3]
Methacrolein
 Probe Info  		N.A.  LDD0218  [3]
NAIA_5
 Probe Info  		C93(0.00); C380(0.00)  LDD2223  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [3]
 LDCM0022  KB02 22RV1 C405(2.66)  LDD2243  [2]
 LDCM0023  KB03 22RV1 C405(3.18)  LDD2660  [2]
 LDCM0024  KB05 NCI-H1650 C405(2.65)  LDD3345  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Neural cell adhesion molecule 2 (NCAM2) . O15394

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264