Details of the Target

General Information of Target

Target ID LDTP00578
Target Name Kynurenine 3-monooxygenase (KMO)
Gene Name KMO
Gene ID 8564
Synonyms
Kynurenine 3-monooxygenase; EC 1.14.13.9; Kynurenine 3-hydroxylase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDSSVIQRKKVAVIGGGLVGSLQACFLAKRNFQIDVYEAREDTRVATFTRGRSINLALSH
RGRQALKAVGLEDQIVSQGIPMRARMIHSLSGKKSAIPYGTKSQYILSVSRENLNKDLLT
AAEKYPNVKMHFNHRLLKCNPEEGMITVLGSDKVPKDVTCDLIVGCDGAYSTVRSHLMKK
PRFDYSQQYIPHGYMELTIPPKNGDYAMEPNYLHIWPRNTFMMIALPNMNKSFTCTLFMP
FEEFEKLLTSNDVVDFFQKYFPDAIPLIGEKLLVQDFFLLPAQPMISVKCSSFHFKSHCV
LLGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFSNDLSLCLPVFSRLRIPDDHAISDLS
MYNYIEMRAHVNSSWFIFQKNMERFLHAIMPSTFIPLYTMVTFSRIRYHEAVQRWHWQKK
VINKGLFFLGSLIAISSTYLLIHYMSPRSFLRLRRPWNWIAHFRNTTCFPAKAVDSLEQI
SNLISR
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Aromatic-ring hydroxylase family, KMO subfamily
Subcellular location
Mitochondrion outer membrane
Function
Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract (Probable).
TTD ID
T50973
Uniprot ID
O15229
DrugMap ID
TTIY56R
Ensemble ID
ENST00000366557.8
HGNC ID
HGNC:6381
ChEMBL ID
CHEMBL2145

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
NB1 SNV: p.S108Y .
NCIH1666 SNV: p.R50C .
RAMOS SNV: p.Q74H .
RD SNV: p.F257L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C341(4.88); C235(1.71); C25(2.70)  LDD3423  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A673 C341(1.37); C235(1.13); C25(1.42)  LDD2261  [1]
 LDCM0023  KB03 A673 C341(2.82); C25(2.05)  LDD2678  [1]
 LDCM0024  KB05 SK-ES1 C341(4.88); C235(1.71); C25(2.70)  LDD3423  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840