Details of the Target

General Information of Target

Target ID LDTP00566
Target Name Villin-like protein (VILL)
Gene Name VILL
Gene ID 50853
Synonyms
Villin-like protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDISKGLPGMQGGLHIWISENRKMVPVPEGAYGNFFEEHCYVILHVPQSPKATQGASSDL
HYWVGKQAGAEAQGAAEAFQQRLQDELGGQTVLHREAQGHESDCFCSYFRPGIIYRKGGL
ASDLKHVETNLFNIQRLLHIKGRKHVSATEVELSWNSFNKGDIFLLDLGKMMIQWNGPKT
SISEKARGLALTYSLRDRERGGGRAQIGVVDDEAKAPDLMQIMEAVLGRRVGSLRAATPS
KDINQLQKANVRLYHVYEKGKDLVVLELATPPLTQDLLQEEDFYILDQGGFKIYVWQGRM
SSLQERKAAFSRAVGFIQAKGYPTYTNVEVVNDGAESAAFKQLFRTWSEKRRRNQKLGGR
DKSIHVKLDVGKLHTQPKLAAQLRMVDDGSGKVEVWCIQDLHRQPVDPKRHGQLCAGNCY
LVLYTYQRLGRVQYILYLWQGHQATADEIEALNSNAEELDVMYGGVLVQEHVTMGSEPPH
FLAIFQGQLVIFQERAGHHGKGQSASTTRLFQVQGTDSHNTRTMEVPARASSLNSSDIFL
LVTASVCYLWFGKGCNGDQREMARVVVTVISRKNEETVLEGQEPPHFWEALGGRAPYPSN
KRLPEEVPSFQPRLFECSSHMGCLVLAEVGFFSQEDLDKYDIMLLDTWQEIFLWLGEAAS
EWKEAVAWGQEYLKTHPAGRSPATPIVLVKQGHEPPTFIGWFFTWDPYKWTSHPSHKEVV
DGSPAAASTISEITAEVNNLRLSRWPGNGRAGAVALQALKGSQDSSENDLVRSPKSAGSR
TSSSVSSTSATINGGLRREQLMHQAVEDLPEGVDPARREFYLSDSDFQDIFGKSKEEFYS
MATWRQRQEKKQLGFF
Target Bioclass
Other
Family
Villin/gelsolin family
Function Possible tumor suppressor.
Uniprot ID
O15195
Ensemble ID
ENST00000283713.10
HGNC ID
HGNC:30906

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
EFO27 SNV: p.G359E .
HUH28 SNV: p.E29K .
KPNYN SNV: p.D646G .
KYSE510 SNV: p.T473S .
MCC13 Substitution: p.R529C .
MDST8 SNV: p.Q427Ter
Substitution: p.N130I		 DBIA    Probe Info 
NALM6 Deletion: p.Y597TfsTer77 .
NCIH2172 SNV: p.G298R .
SW1271 SNV: p.L591V .
TOV21G SNV: p.P111T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C397(0.74)  LDD3321  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 AGS C397(1.43)  LDD2263  [1]
 LDCM0023  KB03 AGS C555(1.46); C397(1.63)  LDD2680  [1]
 LDCM0024  KB05 SH4 C397(0.74)  LDD3321  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840