Details of the Target

General Information of Target

Target ID LDTP00539
Target Name U6 snRNA-associated Sm-like protein LSm1 (LSM1)
Gene Name LSM1
Gene ID 27257
Synonyms
CASM; U6 snRNA-associated Sm-like protein LSm1; Cancer-associated Sm-like; Small nuclear ribonuclear CaSm
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNYMPGTASLIEDIDKKHLVLLRDGRTLIGFLRSIDQFANLVLHQTVERIHVGKKYGDIP
RGIFVVRGENVVLLGEIDLEKESDTPLQQVSIEEILEEQRVEQQTKLEAEKLKVQALKDR
GLSIPRADTLDEY
Target Type
Literature-reported
Target Bioclass
Other
Family
SnRNP Sm proteins family
Subcellular location
Cytoplasm
Function
Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation.
TTD ID
T77344
Uniprot ID
O15116
DrugMap ID
TT2KHSC
Ensemble ID
ENST00000311351.9
HGNC ID
HGNC:20472

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
5E-2FA
 Probe Info  		N.A.  LDD2235  [1]
m-APA
 Probe Info  		N.A.  LDD2231  [1]
Acrolein
 Probe Info  		N.A.  LDD0217  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0109  NEM HeLa N.A.  LDD0223  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Anterior gradient protein 2 homolog (AGR2) AGR family O95994
Anterior gradient protein 3 (AGR3) AGR family Q8TD06
Glutathione S-transferase A4 (GSTA4) Alpha family O15217
Proteasome subunit beta type-5 (PSMB5) Peptidase T1B family P28074
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Chloride intracellular channel protein 1 (CLIC1) Chloride channel CLIC family O00299
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein BEX5 (BEX5) BEX family Q5H9J7
Protein PAT1 homolog 1 (PATL1) PAT1 family Q86TB9
U6 snRNA-associated Sm-like protein LSm2 (LSM2) SnRNP Sm proteins family Q9Y333
U6 snRNA-associated Sm-like protein LSm3 (LSM3) SnRNP Sm proteins family P62310
U6 snRNA-associated Sm-like protein LSm4 (LSM4) SnRNP Sm proteins family Q9Y4Z0
U6 snRNA-associated Sm-like protein LSm6 (LSM6) SnRNP Sm proteins family P62312
T-cell leukemia/lymphoma protein 1B (TCL1B) TCL1 family O95988
Death-associated protein-like 1 (DAPL1) . A0PJW8
Mitochondrial coiled-coil domain protein 1 (MCCD1) . P59942

References

1 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.