Details of the Target

General Information of Target

Target ID LDTP00532
Target Name Syntaphilin (SNPH)
Gene Name SNPH
Gene ID 9751
Synonyms
KIAA0374; Syntaphilin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAMSLPGSRRTSAGSRRRTSPPVSVRDAYGTSSLSSSSNSGSYKGSDSSPTPRRSMKYTL
CSDNHGIKPPTPEQYLTPLQQKEVCIRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQED
WIEEECHRVEAQLALKEARKEIKQLKQVIDTVKNNLIDKDKGLQKYFVDINIQNKKLETL
LHSMEVAQNGMAKEDGTGESAGGSPARSLTRSSTYTKLSDPAVCGDRQPGDPSSGSAEDG
ADSGFAAADDTLSRTDALEASSLLSSGVDCGTEETSLHSSFGLGPRFPASNTYEKLLCGM
EAGVQASCMQERAIQTDFVQYQPDLDTILEKVTQAQVCGTDPESGDRCPELDAHPSGPRD
PNSAVVVTVGDELEAPEPITRGPTPQRPGANPNPGQSVSVVCPMEEEEEAAVAEKEPKSY
WSRHYIVDLLAVVVPAVPTVAWLCRSQRRQGQPIYNISSLLRGCCTVALHSIRRISCRSL
SQPSPSPAGGGSQL
Target Bioclass
Other
Subcellular location
Membrane
Function Inhibits SNARE complex formation by absorbing free STX1A.
Uniprot ID
O15079
Ensemble ID
ENST00000381867.6
HGNC ID
HGNC:15931

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C268(2.68)  LDD3419  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 BRX211 C268(1.90)  LDD2268  [1]
 LDCM0023  KB03 BRX211 C268(2.07)  LDD2685  [1]
 LDCM0024  KB05 SH-4 C268(2.68)  LDD3419  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840