Details of the Target

General Information of Target

Target ID LDTP00406
Target Name Ectoderm-neural cortex protein 1 (ENC1)
Gene Name ENC1
Gene ID 8507
Synonyms
KLHL37; NRPB; PIG10; Ectoderm-neural cortex protein 1; ENC-1; Kelch-like protein 37; Nuclear matrix protein NRP/B; p53-induced gene 10 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSVSVHENRKSRASSGSINIYLFHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRTFPCH
RAVLAACSRYFEAMFSGGLKESQDSEVNFDNSIHPEVLELLLDYAYSSRVIINEENAESL
LEAGDMLEFQDIRDACAEFLEKNLHPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIR
KNEDFLQLPQDMVVQLLSSEELETEDERLVYESAINWISYDLKKRYCYLPELLQTVRLAL
LPAIYLMENVAMEELITKQRKSKEIVEEAIRCKLKILQNDGVVTSLCARPRKTGHALFLL
GGQTFMCDKLYLVDQKAKEIIPKADIPSPRKEFSACAIGCKVYITGGRGSENGVSKDVWV
YDTLHEEWSKAAPMLVARFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPT
INKWTMVAPLREGVSNAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQ
PWRYTAAAVLGNQIFIMGGDTEFSACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKL
YVVGGYFGIQRCKTLDCYDPTLDVWNSITTVPYSLIPTAFVSTWKHLPS
Target Bioclass
Other
Subcellular location
Nucleus matrix
Function
Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin-mediated proteasomal degradation mechanism.
Uniprot ID
O14682
Ensemble ID
ENST00000302351.9
HGNC ID
HGNC:3345

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CHL1 SNV: p.R431Ter .
COLO792 SNV: p.E254K .
HT115 SNV: p.E332Ter .
LS180 SNV: p.Q42P .
MCC13 SNV: p.E81D; p.I576T .
MFE319 SNV: p.A243D .
NCIH1155 SNV: p.R180K .
NCIH358 SNV: p.T284P .
SKOV3 Deletion: p.Y104PfsTer87 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C464(1.27); C468(1.27)  LDD0078  [1]
NAIA_4
 Probe Info  		C227(0.00); C340(0.00)  LDD2226  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0020  ARS-1620 HCC44 C464(1.27); C468(1.27)  LDD0078  [1]
 LDCM0022  KB02 AGS C67(2.13); C59(3.68)  LDD2263  [3]
 LDCM0023  KB03 AGS C67(3.60); C59(4.12)  LDD2680  [3]
 LDCM0024  KB05 NCI-N87 C67(2.00); C59(1.84)  LDD3364  [3]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840