Details of the Target

General Information of Target

Target ID LDTP00393
Target Name Axonemal dynein light intermediate polypeptide 1 (DNALI1)
Gene Name DNALI1
Gene ID 7802
Synonyms
Axonemal dynein light intermediate polypeptide 1; Inner dynein arm light chain, axonemal; hp28
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MIPPADSLLKYDTPVLVSRNTEKRSPKARLLKVSPQQPGPSGSAPQPPKTKLPSTPCVPD
PTKQAEEILNAILPPREWVEDTQLWIQQVSSTPSTRMDVVHLQEQLDLKLQQRQARETGI
CPVRRELYSQCFDELIREVTINCAERGLLLLRVRDEIRMTIAAYQTLYESSVAFGMRKAL
QAEQGKSDMERKIAELETEKRDLERQVNEQKAKCEATEKRESERRQVEEKKHNEEIQFLK
RTNQQLKAQLEGIIAPKK
Target Bioclass
Other
Family
Inner dynein arm light chain family
Subcellular location
Cell projection, cilium
Function Involved in sperm flagellum assembly.
Uniprot ID
O14645
Ensemble ID
ENST00000652629.1
HGNC ID
HGNC:14353

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.F174L; p.M176T .
L428 SNV: p.A163V .
VCAP SNV: p.N142K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C121(2.27)  LDD3439  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 ECC2 C121(2.07)  LDD2320  [1]
 LDCM0023  KB03 ECC2 C121(2.42)  LDD2737  [1]
 LDCM0024  KB05 SNU-1196 C121(2.27)  LDD3439  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840