General Information of Target

Target ID LDTP00388
Target Name Late cornified envelope protein 2B (LCE2B)
Gene Name LCE2B
Gene ID 26239
Synonyms
LEP10; SPRL1B; XP5; Late cornified envelope protein 2B; Late envelope protein 10; Skin-specific protein Xp5; Small proline-rich-like epidermal differentiation complex protein 1B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSCQQNQQQCQPPPKCPPKCTPKCPPKCPPKCLPQCPAPCSPAVSSCCGPISGGCCGPSS
GGCCNSGAGGCCLSHHRPRLFHRRRHQSPDCCESEPSGGSGCCHSSGGCC
Target Bioclass
Other
Family
LCE family
Function Precursors of the cornified envelope of the stratum corneum.
Uniprot ID
O14633
Ensemble ID
ENST00000368780.4
HGNC ID
HGNC:16610

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info 
C20(1.91)  LDD2120  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C20(1.91)  LDD2120  [1]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761