General Information of Target

Target ID LDTP00370
Target Name Heat shock protein beta-6 (HSPB6)
Gene Name HSPB6
Gene ID 126393
Synonyms
Heat shock protein beta-6; HspB6; Heat shock 20 kDa-like protein p20
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEIPVPVQPSWLRRASAPLPGLSAPGRLFDQRFGEGLLEAELAALCPTTLAPYYLRAPSV
ALPVAQVPTDPGHFSVLLDVKHFSPEEIAVKVVGEHVEVHARHEERPDEHGFVAREFHRR
YRLPPGVDPAAVTSALSPEGVLSIQAAPASAQAPPPAAAK
Target Bioclass
Other
Family
Small heat shock protein (HSP20) family
Subcellular location
Cytoplasm
Function
Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Seems to have versatile functions in various biological processes. Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility. May regulate myocardial angiogenesis implicating KDR. Overexpression mediates cardioprotection and angiogenesis after induced damage. Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity.
Uniprot ID
O14558
Ensemble ID
ENST00000004982.6
HGNC ID
HGNC:26511

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C46(1.89)  LDD3340  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 42-MG-BA C46(1.21)  LDD2244  [1]
 LDCM0023  KB03 A204 C46(2.02)  LDD2669  [1]
 LDCM0024  KB05 NB1 C46(1.89)  LDD3340  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840