Details of the Target
General Information of Target
| Target ID | LDTP00331 | |||||
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| Target Name | Nuclear factor 1 B-type (NFIB) |
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| Gene Name | NFIB | |||||
| Gene ID | 4781 | |||||
| Synonyms |
Nuclear factor 1 B-type; NF1-B; Nuclear factor 1/B; CCAAT-box-binding transcription factor; CTF; Nuclear factor I/B; NF-I/B; NFI-B; TGGCA-binding protein |
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| 3D Structure | ||||||
| Sequence |
MMYSPICLTQDEFHPFIEALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDE
LLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLSNPDQKGKIRRIDC LRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFL AYYVQEQDSGQSGSPSHNDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFP IGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTGDFYPSPSSPAAGS RTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTP PPPSPLPFPTQAILPPAPSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQSWYLG |
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| Target Bioclass |
Transcription factor
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| Family |
CTF/NF-I family
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| Subcellular location |
Nucleus
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| Function |
Transcriptional activator of GFAP, essential for proper brain development. Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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m-APA Probe Info |
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15.00 | LDD0402 | [1] | |
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IA-alkyne Probe Info |
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N.A. | LDD0162 | [2] | |
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NAIA_4 Probe Info |
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N.A. | LDD2226 | [3] | |
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NAIA_5 Probe Info |
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N.A. | LDD2223 | [3] | |
Competitor(s) Related to This Target
The Interaction Atlas With This Target
References