Details of the Target

General Information of Target

Target ID LDTP00309
Target Name Receptor-binding cancer antigen expressed on SiSo cells (EBAG9)
Gene Name EBAG9
Gene ID 9166
Synonyms
RCAS1; Receptor-binding cancer antigen expressed on SiSo cells; Cancer-associated surface antigen RCAS1; Estrogen receptor-binding fragment-associated gene 9 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAITQFRLFKFCTCLATVFSFLKRLICRSGRGRKLSGDQITLPTTVDYSSVPKQTDVEEW
TSWDEDAPTSVKIEGGNGNVATQQNSLEQLEPDYFKDMTPTIRKTQKIVIKKREPLNFGI
PDGSTGFSSRLAATQDLPFIHQSSELGDLDTWQENTNAWEEEEDAAWQAEEVLRQQKLAD
REKRAAEQQRKKMEKEAQRLMKKEQNKIGVKLS
Target Bioclass
Other
Subcellular location
Golgi apparatus membrane
Function May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases.
Uniprot ID
O00559
Ensemble ID
ENST00000337573.10
HGNC ID
HGNC:3123

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CALU6 SNV: p.L87F .
HEC1 SNV: p.W63C .
SNGM Deletion: p.L42AfsTer5 .
WM1552C SNV: p.S29F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C12(0.75)  LDD1509  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C12(0.75)  LDD1509  [1]
 LDCM0278  AC19 HEK-293T C12(1.10)  LDD1517  [1]
 LDCM0287  AC27 HEK-293T C12(1.05)  LDD1526  [1]
 LDCM0290  AC3 HEK-293T C12(0.88)  LDD1529  [1]
 LDCM0296  AC35 HEK-293T C12(1.24)  LDD1535  [1]
 LDCM0305  AC43 HEK-293T C12(1.01)  LDD1544  [1]
 LDCM0314  AC51 HEK-293T C12(1.21)  LDD1553  [1]
 LDCM0322  AC59 HEK-293T C12(0.88)  LDD1561  [1]
 LDCM0406  CL19 HEK-293T C12(1.42)  LDD1610  [1]
 LDCM0420  CL31 HEK-293T C12(0.87)  LDD1624  [1]
 LDCM0433  CL43 HEK-293T C12(0.91)  LDD1637  [1]
 LDCM0446  CL55 HEK-293T C12(1.00)  LDD1649  [1]
 LDCM0459  CL67 HEK-293T C12(1.03)  LDD1662  [1]
 LDCM0462  CL7 HEK-293T C12(0.89)  LDD1665  [1]
 LDCM0472  CL79 HEK-293T C12(1.42)  LDD1675  [1]
 LDCM0486  CL91 HEK-293T C12(1.40)  LDD1689  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402