Details of the Target

General Information of Target

Target ID LDTP00304
Target Name Uroplakin-2 (UPK2)
Gene Name UPK2
Gene ID 7379
Synonyms
Uroplakin-2; UP2; Uroplakin II; UPII
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPLLPIRTLPLILILLALLSPGAADFNISSLSGLLSPALTESLLVALPPCHLTGGNATL
MVRRANDSKVVTSSFVVPPCRGRRELVSVVDSGAGFTVTRLSAYQVTNLVPGTKFYISYL
VKKGTATESSREIPMSTLPRRNMESIGLGMARTGGMVVITVLLSVAMFLLVLGFIIALAL
GSRK
Target Bioclass
Transporter and channel
Family
Uroplakin-2 family
Subcellular location
Cell membrane
Function
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in regulating the assembly of the AUM.
Uniprot ID
O00526
Ensemble ID
ENST00000264031.3
HGNC ID
HGNC:12579

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C80(1.96)  LDD3452  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A-549 C80(1.16)  LDD2260  [1]
 LDCM0023  KB03 ABC-1 C80(7.55)  LDD2679  [1]
 LDCM0024  KB05 SW1116 C80(1.96)  LDD3452  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840