Details of the Target
General Information of Target
| Target ID | LDTP00291 | |||||
|---|---|---|---|---|---|---|
| Target Name | Butyrophilin subfamily 3 member A1 (BTN3A1) | |||||
| Gene Name | BTN3A1 | |||||
| Gene ID | 11119 | |||||
| Synonyms |
BTF5; Butyrophilin subfamily 3 member A1; CD antigen CD277 |
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| 3D Structure | ||||||
| Sequence |
MKMASFLAFLLLNFRVCLLLLQLLMPHSAQFSVLGPSGPILAMVGEDADLPCHLFPTMSA
ETMELKWVSSSLRQVVNVYADGKEVEDRQSAPYRGRTSILRDGITAGKAALRIHNVTASD SGKYLCYFQDGDFYEKALVELKVAALGSDLHVDVKGYKDGGIHLECRSTGWYPQPQIQWS NNKGENIPTVEAPVVADGVGLYAVAASVIMRGSSGEGVSCTIRSSLLGLEKTASISIADP FFRSAQRWIAALAGTLPVLLLLLGGAGYFLWQQQEEKKTQFRKKKREQELREMAWSTMKQ EQSTRVKLLEELRWRSIQYASRGERHSAYNEWKKALFKPADVILDPKTANPILLVSEDQR SVQRAKEPQDLPDNPERFNWHYCVLGCESFISGRHYWEVEVGDRKEWHIGVCSKNVQRKG WVKMTPENGFWTMGLTDGNKYRTLTEPRTNLKLPKPPKKVGVFLDYETGDISFYNAVDGS HIHTFLDVSFSEALYPVFRILTLEPTALTICPA |
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| Target Bioclass |
Immunoglobulin
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| Family |
Immunoglobulin superfamily, BTN/MOG family
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| Subcellular location |
Cell membrane
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| Function |
Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
| ChEMBL ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| 8305C | SNV: p.L24V | DBIA Probe Info | |||
| FTC133 | SNV: p.L18F | DBIA Probe Info | |||
| IGROV1 | SNV: p.V306M | . | |||
| KYSE410 | SNV: p.D149N | DBIA Probe Info | |||
| LS180 | SNV: p.V497D | . | |||
| NCIH716 | SNV: p.Q417L | . | |||
| SISO | SNV: p.A245T | DBIA Probe Info | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C511(1.01) | LDD3313 | [1] | |
Competitor(s) Related to This Target