Details of the Target

General Information of Target

Target ID LDTP00290
Target Name Butyrophilin subfamily 3 member A3 (BTN3A3)
Gene Name BTN3A3
Gene ID 10384
Synonyms
BTF3; Butyrophilin subfamily 3 member A3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKMASSLAFLLLNFHVSLFLVQLLTPCSAQFSVLGPSGPILAMVGEDADLPCHLFPTMSA
ETMELRWVSSSLRQVVNVYADGKEVEDRQSAPYRGRTSILRDGITAGKAALRIHNVTASD
SGKYLCYFQDGDFYEKALVELKVAALGSDLHIEVKGYEDGGIHLECRSTGWYPQPQIKWS
DTKGENIPAVEAPVVADGVGLYAVAASVIMRGSSGGGVSCIIRNSLLGLEKTASISIADP
FFRSAQPWIAALAGTLPISLLLLAGASYFLWRQQKEKIALSRETEREREMKEMGYAATEQ
EISLREKLQEELKWRKIQYMARGEKSLAYHEWKMALFKPADVILDPDTANAILLVSEDQR
SVQRAEEPRDLPDNPERFEWRYCVLGCENFTSGRHYWEVEVGDRKEWHIGVCSKNVERKK
GWVKMTPENGYWTMGLTDGNKYRALTEPRTNLKLPEPPRKVGIFLDYETGEISFYNATDG
SHIYTFPHASFSEPLYPVFRILTLEPTALTICPIPKEVESSPDPDLVPDHSLETPLTPGL
ANESGEPQAEVTSLLLPAHPGAEVSPSATTNQNHKLQARTEALY
Target Bioclass
Immunoglobulin
Family
Immunoglobulin superfamily, BTN/MOG family
Subcellular location
Cell membrane
Function Plays a role in T-cell responses in the adaptive immune response.
Uniprot ID
O00478
Ensemble ID
ENST00000244519.7
HGNC ID
HGNC:1140

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HS839T SNV: p.T426I DBIA    Probe Info 
IPC298 SNV: p.P538S DBIA    Probe Info 
NB1 SNV: p.V21F DBIA    Probe Info 
RH30 SNV: p.Q246Ter DBIA    Probe Info 
SNGM SNV: p.A253V DBIA    Probe Info 
YSCCC SNV: p.L371M DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OPA-S-S-alkyne
 Probe Info  		K83(1.19); K108(2.27)  LDD3494  [1]
DBIA
 Probe Info  		C22(1.85)  LDD3311  [2]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [3]
NAIA_5
 Probe Info  		N.A.  LDD2224  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 22RV1 C22(2.41)  LDD2243  [2]
 LDCM0023  KB03 22RV1 C22(1.97)  LDD2660  [2]
 LDCM0024  KB05 G361 C22(1.85)  LDD3311  [2]

References

1 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264