Details of the Target

General Information of Target

Target ID LDTP00278
Target Name GDNF family receptor alpha-2 (GFRA2)
Gene Name GFRA2
Gene ID 2675
Synonyms
GDNFRB; RETL2; TRNR2; GDNF family receptor alpha-2; GDNF receptor alpha-2; GDNFR-alpha-2; GFR-alpha-2; GDNF receptor beta; GDNFR-beta; Neurturin receptor alpha; NRTNR-alpha; NTNR-alpha; RET ligand 2; TGF-beta-related neurotrophic factor receptor 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MILANVFCLFFFLDETLRSLASPSSLQGPELHGWRPPVDCVRANELCAAESNCSSRYRTL
RQCLAGRDRNTMLANKECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGE
EFYEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSS
YISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPS
CSYEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPADNYQACLGSYAGM
IGFDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTENPCLRNAIQAFGNGTD
VNVSPKGPSFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSVQEQGLKANNSKELSM
CFTELTTNIIPGSNKVIKPNSGPSRARPSAALTVLSVLMLKLAL
Target Bioclass
Other
Family
GDNFR family
Subcellular location
Cell membrane
Function
Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.; [Isoform 2]: Participates in NRTN-induced 'Ser-727' phosphorylation of STAT3.
Uniprot ID
O00451
Ensemble ID
ENST00000517328.5
HGNC ID
HGNC:4244

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.T281R .
HT115 SNV: p.R205H .
IGR1 SNV: p.G256D .
LS123 SNV: p.G98C .
MCC13 SNV: p.P29S .
MEWO SNV: p.P365S .
SKES1 SNV: p.A298G .
SKNSH SNV: p.E334Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		N.A.  LDD2223  [1]

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264