Details of the Target
General Information of Target
| Target ID | LDTP00258 | |||||
|---|---|---|---|---|---|---|
| Target Name | Forkhead box protein E1 (FOXE1) | |||||
| Gene Name | FOXE1 | |||||
| Gene ID | 2304 | |||||
| Synonyms |
FKHL15; FOXE2; TITF2; TTF2; Forkhead box protein E1; Forkhead box protein E2; Forkhead-related protein FKHL15; HFKH4; HNF-3/fork head-like protein 5; HFKL5; Thyroid transcription factor 2; TTF-2 |
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| 3D Structure | ||||||
| Sequence |
MTAESGPPPPQPEVLATVKEERGETAAGAGVPGEATGRGAGGRRRKRPLQRGKPPYSYIA
LIAMAIAHAPERRLTLGGIYKFITERFPFYRDNPKKWQNSIRHNLTLNDCFLKIPREAGR PGKGNYWALDPNAEDMFESGSFLRRRKRFKRSDLSTYPAYMHDAAAAAAAAAAAAAAAAI FPGAVPAARPPYPGAVYAGYAPPSLAAPPPVYYPAASPGPCRVFGLVPERPLSPELGPAP SGPGGSCAFASAGAPATTTGYQPAGCTGARPANPSAYAAAYAGPDGAYPQGAGSAIFAAA GRLAGPASPPAGGSSGGVETTVDFYGRTSPGQFGALGACYNPGGQLGGASAGAYHARHAA AYPGGIDRFVSAM |
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| Target Bioclass |
Transcription factor
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| Subcellular location |
Nucleus
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| Function |
Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. Involved in proper palate formation, most probably through the expression of MSX1 and TGFB3 genes which are direct targets of this transcription factor. Also implicated in thyroid gland morphogenesis. May indirectly play a role in cell growth and migration through the regulation of WNT5A expression.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C224(1.37) | LDD3310 | [1] | |
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NAIA_5 Probe Info |
 |
N.A. | LDD2224 | [2] | |
Competitor(s) Related to This Target
References