Details of the Target

General Information of Target

Target ID LDTP00255
Target Name Sulfotransferase 1C2 (SULT1C2)
Gene Name SULT1C2
Gene ID 6819
Synonyms
SULT1C1; Sulfotransferase 1C2; ST1C2; EC 2.8.2.1; Sulfotransferase 1C1; SULT1C#1; humSULTC2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALTSDLGKQIKLKEVEGTLLQPATVDNWSQIQSFEAKPDDLLICTYPKAGTTWIQEIVD
MIEQNGDVEKCQRAIIQHRHPFIEWARPPQPSGVEKAKAMPSPRILKTHLSTQLLPPSFW
ENNCKFLYVARNAKDCMVSYYHFQRMNHMLPDPGTWEEYFETFINGKVVWGSWFDHVKGW
WEMKDRHQILFLFYEDIKRDPKHEIRKVMQFMGKKVDETVLDKIVQETSFEKMKENPMTN
RSTVSKSILDQSISSFMRKGTVGDWKNHFTVAQNERFDEIYRRKMEGTSINFCMEL
Target Bioclass
Enzyme
Family
Sulfotransferase 1 family
Subcellular location
Cytoplasm
Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic compounds. Does not sulfonate steroids, dopamine, acetaminophen, or alpha-naphthol. Catalyzes the sulfonation of the carcinogenic N-Hydroxy-2-acetylaminofluorene leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis.
Uniprot ID
O00338
Ensemble ID
ENST00000251481.11
HGNC ID
HGNC:11456
ChEMBL ID
CHEMBL1743295

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEL Substitution: p.F126_L127delinsLI .
HEL9217 Substitution: p.F126_L127delinsLI .
HGC27 SNV: p.M100L .
IGR37 SNV: p.T4I; p.G18R .
IGR39 SNV: p.T4I; p.G18R .
MDAMB468 SNV: p.E158K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C135(1.48)  LDD3368  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 HuH-1 C304(1.43)  LDD2374  [1]
 LDCM0023  KB03 A2780 C135(2.01)  LDD2671  [1]
 LDCM0024  KB05 OAW-28 C135(1.48)  LDD3368  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840